Research progress of synthetic methods of ［<sup>18</sup>F］F-DOPA

CHENG Weihua; GUO Feihu; DENG Xuesong; QIN Xiangyu; FAN Hongqiang; HU Ji

doi:10.11665/j.issn.1000-5048.20190313

Journal of China Pharmaceutical University > 2019 > 50(3): 357-363. > DOI: 10.11665/j.issn.1000-5048.20190313

CHENG Weihua, GUO Feihu, DENG Xuesong, QIN Xiangyu, FAN Hongqiang, HU Ji. Research progress of synthetic methods of ［¹⁸F］F-DOPA[J]. Journal of China Pharmaceutical University, 2019, 50(3): 357-363. DOI: 10.11665/j.issn.1000-5048.20190313

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Research progress of synthetic methods of ［¹⁸F］F-DOPA

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Abstract

［¹⁸F］6-fluoro-3, 4-dihydroxy-L-phenylalanine(［¹⁸F］F-DOPA)has been used as a radiotracer for Parkinson′s disease over 30 years. The previously reported electrophilic synthesis method has low radiochemical yield(RCY), low specific activity(SA)and other defects. Recent reported nucleophilic synthesis of ［¹⁸F］F-DOPA could overcome the disadvantages. In this paper, the nucleophilic synthetic methods for ［¹⁸F］F-DOPA are reviewed.
- ［¹⁸F］6-fluoro-3,4-dihydroxy-L-phenylalanine,
- nucleophilic substitution,
- fluorination,
- radiochemical synthesis

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