Advanced Search
LEI Yajuan, XIONG Yerong, ZHU Yanyue, DUAN Mengru, SUN Chunmeng, HE Dongsheng, TU Jiasheng. Determination of ethylene glycol, diethylene glycol and triethylene glycol in poloxamer 188 by gas chromatography[J]. Journal of China Pharmaceutical University, 2019, 50(6): 694-698. DOI: 10.11665/j.issn.1000-5048.20190609
Citation: LEI Yajuan, XIONG Yerong, ZHU Yanyue, DUAN Mengru, SUN Chunmeng, HE Dongsheng, TU Jiasheng. Determination of ethylene glycol, diethylene glycol and triethylene glycol in poloxamer 188 by gas chromatography[J]. Journal of China Pharmaceutical University, 2019, 50(6): 694-698. DOI: 10.11665/j.issn.1000-5048.20190609
shu

Determination of ethylene glycol, diethylene glycol and triethylene glycol in poloxamer 188 by gas chromatography

More Information
    Graphical Abstract
    • Abstract
  • The gas chromatography method was developed for the determination of ethylene glycol, diethylene glycol and triethylene glycol in poloxamer 188 to provide scientific basis for the quality control. The samples was separated on column VF-17ms(30 m×0. 53 mm, 1. 0 μm)with temperature programming, inlet temperature was 270 °C, detector temperature was 290 °C and the split ratio was 10 ∶1. The method showed great linearity over the range of 6-15 μg/mL(r≥0. 999). The injection precision(n=8)of the three residual impurities were 3. 3%, 3. 0%, 2. 3% and the average recoveries were 99. 05%(RSD=2. 9%, n=9), 102. 20%(RSD=4. 0%, n=9), 101. 91%(RSD=3. 1%, n=9), respectively. The analytical method is specific, accurate and sensitive, which is suitable for the determination of ethylene glycol, diethylene glycol and triethylene glycol in poloxamer 188, providing reference and guidance for the production and quality control of poloxamer 188.
    • FullText(HTML)
    • References (15)
  • [1]
    Paavola A,Bernards CM,Rosenberg PH.Controlled release ibuprofen-poloxamer gel for epidural use:a pharmacokinetic study using microdialysis in pigs[J].Eur J Pharm Biopharm,2016,108:180-186.
    [2]
    Bujňáková Z,BalហM,Zdurieníková M,et al.Preparation,properties and anticancer effects of mixed As4S4/ZnS nanoparticles capped by Poloxamer 407[J].Mater Sci Eng C Mater Biol Appl,2017,71:541-551.
    [3]
    Liu DF,Jiang T,Cai WH,et al.An in situ gelling drug delivery system for improved recovery after spinal cord injury[J].Adv Healthc Mater,2016,5(12):1513-1521.
    [4]
    Mao J,Liu SJ,Ai M,et al.A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety[J].J Hematol Oncol,2017,10(1):71.
    [5]
    Yu SH,Zhang XY,Tan GX,et al.A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery[J].Carbohydr Polym,2017,155:208-217.
    [6]
    Nagesh IV,Koley KC,Sen S,et al.Ethylene glycol poisoning[J].Med J Armed Forces India,2015,71(Suppl 1):S36-S38.
    [7]
    Fowles J,Banton M,Klapacz J,et al.A toxicological review of the ethylene glycol series:commonalities and differences in toxicity and modes of action[J].Toxicol Lett,2017,278:66-83.
    [8]
    Schep LJ,Slaughter RJ,Temple WA,et al.Diethylene glycol poisoning[J].Clin Toxicol,2009,47(6):525-535.
    [9]
    Devoti E,Marta E,Belotti E,et al.Diethylene glycol poisoning from transcutaneous absorption[J].Am J Kidney Dis,2015,65(4):603-606.
    [10]
    Chinese Pharmacopoeia Commission.Chinese Pharmacopoeia:part 4(中华人民共和国药典:四部)[S].Beijing:China Medical Science Press,2015:530-531.
    [11]
    Li LL,Wang HP,Tian HW,et al.Determination of 6 residual solvents in selexipag by headspace gas chromatography[J].J China Pharm Univ(中国药科大学学报),2018,49(1):93-96.
    [12]
    Imbert L, Saussereau E, Lacroix C. Analysis of eight glycols in serum using LC-ESI-MS-MS[J].J Anal Toxicol,2014,38(9):676-680.
    [13]
    Teglia CM,Montemurro M,De Zan MM,et al.Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals[J].J Pharm Anal,2015,5(5):296-306.
    [14]
    Fan CL,Zhang YH,Wang C,et al.Determination of purity and impurities of ethylene glycol for industrial use by gas chromatography[J].Chin J Chromatogr(色谱),2019,37(1):116-120.
    [15]
    Qin XY,Wu RR,Shen Y,et al.Effects of polysorbate 80 of different sources on the quality of docetaxel injection[J].J China Pharm Univ(中国药科大学学报),2012,43(4):312-317.
    • Related Articles

  • Related Articles

    [1]Non-traditional antiarrhythmic medicines for atrial fibrillation[J]. Journal of China Pharmaceutical University, 2010, 41(1): 86-90.
    [2]Synthesis and Antiarrhythmic Activity of Protoberberine Quaternary Ammonium Compounds[J]. Journal of China Pharmaceutical University, 2003, (1): 9-14.
    [3]Synthesis and Antiarrhythmic Activity of Some Methyl sulfonamido phenylethylamino Derivatives[J]. Journal of China Pharmaceutical University, 1999, (1): 9-14.
    [4]QSARStudyonAntiarhythmicActivityofSomeMethanesulfonamidoPhenethylaminoDerivativesJiMin,LiuHong,JinSong,LiuLigang,HuaWeiyi,JiNianningDivisionofMedicinalChemistry,ChinaPharmaceuticalUniversity,Nanjing210009AbstractStructuresof12substitutedmethanesulfonamido[J]. Journal of China Pharmaceutical University, 1998, (4): 7-10.
    [5]Synthesis of 3-Substituted Diiodo Benzoylindole Derivatives[J]. Journal of China Pharmaceutical University, 1991, (3): 129-132.
    [6]SYNTHESIS OF 4-ARYL/HETERAYLAMINOMETHYL-PHENOLS[J]. Journal of China Pharmaceutical University, 1988, (3): 167-170+242.
    [7]Fang Chenglin, Liao Qingjiang, Xu Fang. SYNTHESIS OF THE DERIVATIVES OF AULUTON AN ANTIARRHYTHMIC AGENT[J]. Journal of China Pharmaceutical University, 1984, (1): 45-52.
    [8]Hou Dehui, Li Ling, Wang Qiujuan, Chen Guifa. THE COMPARATIVE STUDIES ON THE ANTIHYFOXIC AND ANTIARRHYTHMIC EFFECT OF FIVE PROTO-BERBERINE COMPOUNDS[J]. Journal of China Pharmaceutical University, 1983, (1): 30-33.
    [9]Xu Fang, Liao Jiangqing, Xie Jinrong. The Utilization of Tigogenin Ⅱ.Synthesis of Auluton -- An Antiarrhythmic Agent[J]. Journal of China Pharmaceutical University, 1982, (2): 83-87.
    [10]Xia Lin, Ma Weixi, Yang Yihong, Bao Dongmei. Resolution of (±) Mexiletine -- A New Antiarrhythmic Agent[J]. Journal of China Pharmaceutical University, 1979, (1): 61-63.

  • Cited by

    Periodical cited type(1)

    1. 宋书贤，张钰清，李云冬，李宽，帕成周，高红强. 硫化氢在肝脏疾病中作用的研究进展. 中国普外基础与临床杂志. 2025(03): 367-373 .

    Other cited types(5)

Catalog

    Get Citation
    PDF
    XML
    Article views (751) PDF downloads (1050) Cited by(6)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：454748

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return