Progress in research on the determination of entrapment efficiency of liposomes

ZHANG Yi; HANG Taijun; SONG Min

doi:10.11665/j.issn.1000-5048.20210214

Journal of China Pharmaceutical University > 2021 > 52(2): 245-252. > DOI: 10.11665/j.issn.1000-5048.20210214

ZHANG Yi, HANG Taijun, SONG Min. Progress in research on the determination of entrapment efficiency of liposomes[J]. Journal of China Pharmaceutical University, 2021, 52(2): 245-252. DOI: 10.11665/j.issn.1000-5048.20210214

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Progress in research on the determination of entrapment efficiency of liposomes

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China

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Received Date: December 27, 2020
Revised Date: March 08, 2021

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Abstract

Abstract

Liposome, a new dosage form, has become important in improving in vivo behavior of drugs or realizing targeted drug delivery. Study and control of its critical processes and quality attributes are the main challenges in the current research on liposomes. The degree of encapsulation can determine drug''s effect in vivo directly, thus entrapment efficiency (EE) has turned into one of the critical quality attributes of liposome.In this paper some methods commonly used for the determination of EE and their characteristics are summarized and analyzed, and the main factors to be considered for the determination are discussed.

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