Advance of novel target strategies participating in myocardial ischemia reperfusion injury

HOU Kai; TAN Haoyu; LIU Jing; LI Yunman

doi:10.11665/j.issn.1000-5048.20220205

Journal of China Pharmaceutical University > 2022 > 53(2): 164-170. > DOI: 10.11665/j.issn.1000-5048.20220205

HOU Kai, TAN Haoyu, LIU Jing, LI Yunman. Advance of novel target strategies participating in myocardial ischemia reperfusion injury[J]. Journal of China Pharmaceutical University, 2022, 53(2): 164-170. DOI: 10.11665/j.issn.1000-5048.20220205

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Advance of novel target strategies participating in myocardial ischemia reperfusion injury

1.
Department of Pharmacy, Zhongda Hospital, Southeast University, Nanjing 210009
2.
Cardiovascular Surgery, The Second XiangYa Hospital of Central South University, Changsha 410000
3.
State Key Laboratory of Natural Medicines, Department of Physiology, China Pharmaceutical University, Nanjing 210009, China

Funds: This project was supported by China Pharmaceutical University "Double First-Class" Construction Technology Innovation Team Project (No.CPU2018GY23)

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Received Date: October 27, 2021
Revised Date: February 27, 2022

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Abstract

Abstract

Worldwide morbidity and mortality of acute myocardial infarction (AMI) and related heart failure are still high.While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical and effective treatment at present, collateral myocardial ischemia reperfusion injury (MIRI) and pertinent cardio-protection are still challenging to address and have inadequately understood mechanisms.One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple mechanisms, as well as affecting other cell types, including platelets, fibroblasts, endothelial and smooth muscle cells, and immune cells.Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities.Therefore, unveiling the related multitarget strategies participating in triggering and resisting the pathobiology of MIRI is a promising and valuable frontier.The review specifically focuses on the recent MIRI advances that are supported by multitarget strategies and new targets under development in order to bring the rational combination of multitarget therapies up to date, as well as to identify findings that may facilitate the new drug of novel targets.
- myocardial ischemia,
- ischemia-reperfusion injury,
- multiple targets,
- cardioprotective strategies,
- novel targets,
- advances

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References (38)

References

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