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GAO Jing, MI Xue, ZHOU Qi, ZHOU Jun. Research progress of N6-methyladenine demethylase inhibitors[J]. Journal of China Pharmaceutical University, 2022, 53(6): 663-673. DOI: 10.11665/j.issn.1000-5048.20220604
Citation: GAO Jing, MI Xue, ZHOU Qi, ZHOU Jun. Research progress of N6-methyladenine demethylase inhibitors[J]. Journal of China Pharmaceutical University, 2022, 53(6): 663-673. DOI: 10.11665/j.issn.1000-5048.20220604
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Research progress of N6-methyladenine demethylase inhibitors

  • School of Life Science & Technology, China Pharmaceutical University, Nanjing 211198, China

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  • Received Date: September 04, 2022
  • Revised Date: November 06, 2022
    Graphical Abstract
    • Abstract
  • N6-methyladenine (m6A) modification, the most abundant and dynamic chemical modification on messenger RNA, plays an essential role in physiological and pathological progress.Recent studies have found that tumor progression can be affected by altering the m6A modification level of target genes. Therefore, small molecule targeted m6A demethylase can be used as a new anti-tumor strategy.This review focuses on the regulatory mechanism of m6A demethylases, including fat mass and obesity-associated protein (FTO) and AlkB homlog 5 (ALKBH5), as well as their biological functions in tumors, and summarizes the research progress of their small molecule inhibitors.
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    • References (61)
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