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YANG Ke, YU Tao. Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant[J]. Journal of China Pharmaceutical University, 2022, 53(6): 710-715. DOI: 10.11665/j.issn.1000-5048.20220610
Citation: YANG Ke, YU Tao. Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant[J]. Journal of China Pharmaceutical University, 2022, 53(6): 710-715. DOI: 10.11665/j.issn.1000-5048.20220610
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Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant

  • School of Science, China Pharmaceutical University,Nanjing 210098, China

Funds: This work was supported by the National Natural Science Foundation of China (No.82073809) and the Project of the Ideological and Political Education in Courses of China Pharmaceutical University (Instrumental Analysis Experiment)
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  • Received Date: September 13, 2022
  • Revised Date: October 26, 2022
    Graphical Abstract
    • Abstract
  • In this paper, micellar electrokinetic chromatography (MEKC) with glucose-β-cyclodextrin (Glu-β-CD) as chiral selector and ionic liquid surfactant N-butyl-N-methyl pyrrolidine lauryl sulfate ([C4MP] [C12SO4]) micelles formed at low pH as a pseudo stationary phase was applied for the chiral separation of four acidic drugs naproxen,warfarin, ketoprofen and ibuprofen.Under the same conditions,significantly improved separation of tested drug enantiomers was achieved with the MEKC system based on [C4MP][C12SO4] compared with the system based on the conventional surfactant sodium dodecyl sulfate (SDS).Several primary parameters affecting enantioseparation such as type and proportion of organic modifier, concentration and pH of the running buffer, concentration of chiral selector,concentration of ionic liquid surfactant and applied voltage were systematically investigated.
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    • References (15)
  • [1]
    . Univ Chem（大学化学），2019，34（9）：1-12.
    [2]
    Chen L，Yang P，Ji YB. Chiral separation of esomeprazole and its enantiomer by affinity capillary electrophoresis［J］. J China Pham Univ（中国药科大学学报），2014，45（4）：444-449.
    [3]
    Terabe S，Otsuka K，Ichikawa K，et al. Electrokinetic separations with micellar solutions and open-tubular capillaries［J］. Anal Chem，1984，56（1）：111-113.
    [4]
    Tano C，Son SH，Furukawa J，et al. Enantiomeric separation by MEKC using dodecyl thioglycoside surfactants：importance of an equatorially oriented hydroxy group at C-2 position in separation of dansylated amino acids［J］. Electrophoresis，2009，30（15）：2743-2746.
    [5]
    Evans K，Wang X，Roper MG. Chiral micellar electrokinetic chromatographic separation for determination of L- and D-primary amines released from murine islets of Langerhans［J］. Anal Methods，2019，11（9）：1276-1283.
    [6]
    Salido-Fortuna S，Castro-Puyana M，Marina ML. Chiral micellar electrokinetic chromatography［J］. J Chromatogr A，2020，1626：461383.
    [7]
    Zhuang WC，Hachem K，Bokov D，et al. Ionic liquids in pharmaceutical industry：a systematic review on applications and future perspectives［J］. J Mol Liq，2022，349：118145.
    [8]
    Nie LR，Yohannes A，Yao S. Recent advances in the enantioseparation promoted by ionic liquids and their resolution mechanisms［J］. J Chromatogr A，2020，1626：461384.
    [9]
    Ali I，Suhail M，Sanagi MM，et al. Ionic liquids in HPLC and CE：a hope for future［J］. Crit Rev Anal Chem，2017，47（4）：332-339.
    [10]
    Jiao JJ，Dong B，Zhang HN，et al. Aggregation behaviors of dodecyl sulfate-based anionic surface active ionic liquids in water［J］. J Phys Chem B，2012，116（3）：958-965.
    [11]
    Wasserscheid P，van Hal R，B?smann A. 1-n-butyl-3-methylimidazolium （［bmim］） octylsulfate — an even ‘greener’ionic liquid［J］. Green Chem，2002，4（4）：400-404.
    [12]
    Bessonova E，Kartsova L，Gallyamova V. Ionic liquids based on imidazole for online concentration of catecholamines in capillary electrophoresis［J］. J Sep Sci，2017，40（10）：2304-2311.
    [13]
    Yu T，Zhang JJ，Sun XD，et al. Evaluation of cyclodextrin-micellar electrokinetic capillary chromatography with pyrrolidinium-based ionic liquid surfactant as a pseudostationary phase for chiral separation［J］. Sep Sci Plus，2019，2（4）：137-145.
    [14]
    Borissova M，Palk K，Koel M. Micellar electrophoresis using ionic liquids［J］. J Chromatogr A，2008，1183（1/2）：192195.
    [15]
    Rageh AH，Pyell U. Imidazolium-based ionic liquid-type surfactant as pseudostationary phase in micellar electrokinetic chromatography of highly hydrophilic urinary nucleosides［J］. J Chromatogr A，2013，1316：135-146.
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