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TANG Linfang, YANG Yali, HE Shuwang, YAO Jing. Preparation of azithromycin-ion exchange resin complexes for taste-masking and controlled drug release[J]. Journal of China Pharmaceutical University, 2023, 54(2): 180-187. DOI: 10.11665/j.issn.1000-5048.2023020403
Citation: TANG Linfang, YANG Yali, HE Shuwang, YAO Jing. Preparation of azithromycin-ion exchange resin complexes for taste-masking and controlled drug release[J]. Journal of China Pharmaceutical University, 2023, 54(2): 180-187. DOI: 10.11665/j.issn.1000-5048.2023020403
shu

Preparation of azithromycin-ion exchange resin complexes for taste-masking and controlled drug release

  • 1.

    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210098

  • 2.

    Shandong Dyne Marine Bio-pharmaceutical Co., Ltd., Rongcheng 264300 , China

Funds: The National Science and Technology Major Project
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  • Received Date: February 03, 2023
  • Revised Date: March 26, 2023
    Graphical Abstract
    • Abstract
  • In order to mask the bitterness of azithromycin (AZI) and individually regulate the drug release rate to reduce gastrointestinal irritation, immediate-release AZI-AmberliteTM IRP64/HPC and delayed-release AZI-AmberliteTM IRP69/RS100 were prepared by modifying with hydroxypropyl cellulose (HPC) and Eudragit RS100, respectively, and further combined to achieve controlled release.The drug loading and drug utilization rate of AZI-ion exchange resin complexes were measured; the structure of AZI-ion exchange resin complexes was characterized by differential scanning calorimetry and X-ray diffraction; and the wetting humidity, odor masking effects, in vitro dissolution and release behaviors were determined.The results showed that the formation of AZI-ion exchange resin complexes changed the original crystallization state of the drug, that the 2.5% HPC-modified AZI-AmberliteTM IRP64/HPC and the 0.5% RS100-modified AZI-AmberliteTM IRP69/RS100 demonstrated good taste masking effect, and that their combination in the drug content ratio of 13∶67 achieved the expected drug release behavior, i.e.rapid release of AZI in the first 10 min and smooth release in the later 6 h.These results indicated that the AZI-ion exchange resin complexes prepared by surface modification and their composites could mask the bitterness of AZI and realize the flexible adjustment of drug release rate, which lays the foundation for the research and development of new AZI preparations.
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    • References (19)
  • [1]
    Wang YJ, Zhu CM, Li GP, et al. Effect of azithromycin on symptom recovery and prognosis in children with mycoplasma pneumonia[J]. China Med (中国医药), 2020, 15(2): 212-215.
    [2]
    Huang Q, Cao MZ. Evaluation of the effectiveness of azithromycin in the treatment of mycoplasma pneumonia in children[J]. Shenzhen J Integr Tradit Chin West Med (深圳中西医结合杂志), 2021,31(21):190-192.
    [3]
    Xiao Z, Li Z, Sun YY, et al. Review of taste masking techniques in Chinese patent medicine[J]. China J Chin Mater Med (中国中药杂志), 2021, 46(2): 333-339.
    [4]
    Li NJ, Feng YR, Wang RN, et al. Review on the application of common formulations and generic techniques of children''s Chinese medicine preparations[J]. J Nanjing Univ Tradit Chin Med(南京中医药大学学报), 2022, 38(9): 780-789.
    [5]
    Hai LL, Zhu L, Li ZP. Review of excipients safety in pediatric patients[J]. Chin Pharm J (中国药学杂志), 2019, 54(14): 1121-1125.
    [6]
    Shil A, Chichger H. Artificial sweeteners negatively regulate pathogenic characteristics of two model gut bacteria, E. coli and E. faecalis[J]. Int J Mol Sci, 2021, 22(10): 5228.
    [7]
    Fan YL, Chen H, Huang ZW, et al. Taste-masking and colloidal-stable cubosomes loaded with cefpodoxime proxetil for pediatric oral delivery[J]. Int J Pharm, 2020, 575: 118875.
    [8]
    Hu XY, Lou H, Hageman MJ. Preparation of lapatinib ditosylate solid dispersions using solvent rotary evaporation and hot melt extrusion for solubility and dissolution enhancement[J]. Int J Pharm, 2018, 552(1/2):154-163.
    [9]
    Repka MA, Battu SK, Upadhye SB, et al. Pharmaceutical applications of hot-melt extrusion: part II[J]. Drug Dev Ind Pharm, 2007, 33(10): 1043-1057.
    [10]
    He BL, Huang WQ. Ion exchange and adsorption resins (离子交换与吸附树脂)[M]. Shanghai: Shanghai Scientific and Technological Education Publishing House, 1995: 4.
    [11]
    Rajesh AM, Popat KM. Taste masking of azithromycin by resin complex and sustained release through interpenetrating polymer network with functionalized biopolymers[J]. Drug Dev Ind Pharm, 2017, 43(5): 732-741.
    [12]
    Ali MA, Razafindralambo HL, Conti G, et al. Bulk and surface wettability characteristics of probiotic powders in their compressed disc and packed-bed column forms[J]. ACS Omega, 2020, 5(35): 22348-22355.
    [13]
    Chanut J, Wang YQ, Gougeon RD, et al. Unraveling the complex interfacial properties of cork-based materials in their use as wine stoppers[J]. ACS Appl Mater Interfaces, 2022,14(37):42602-42612.
    [14]
    Shang R, Liu C, Quan P, et al. Effect of drug-ion exchange resin complex in betahistine hydrochloride orodispersible film on sustained release, taste masking and hygroscopicity reduction[J]. Int J Pharm, 2018, 545(1/2): 163-169.
    [15]
    Khan S, Guha A, Yeole PG, et al. Strong cation exchange resin for improving physicochemical properties and sustaining release of ranitidine hydrochloride[J]. Indian J Pharm Sci, 2007, 69(5): 626.
    [16]
    Jaine JE, Mucalo MR. Measurements of the wettability of catalyst support materials using the Washburn capillary rise technique[J]. Powder Technol, 2015, 276: 123-128.
    [17]
    Alghunaim A, Kirdponpattara S, Newby BM Z. Techniques for determining contact angle and wettability of powders[J]. Powder Technol, 2016, 287: 201-215.
    [18]
    Jayasundar R, Ghatak S. Spectroscopic and E-tongue evaluation of medicinal plants: a taste of how rasa can be studied[J]. J Ayurveda Integr Med, 2016, 7(4): 191-197.
    [19]
    Newman J, O''Riordan D, Jacquier JC, et al. Masking of bitterness in dairy protein hydrolysates: comparison of an electronic tongue and a trained sensory panel as means of directing the masking strategy[J]. LWT-Food Sci Technol, 2015, 63(1):751-757.
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