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LAN Aili, LIU Gang, WU Chaoran, et al. Research progress of integrated stress response in central nervous system diseases[J]. J China Pharm Univ, 2024, 55(2): 194 − 201. DOI: 10.11665/j.issn.1000-5048.2023112302
Citation: LAN Aili, LIU Gang, WU Chaoran, et al. Research progress of integrated stress response in central nervous system diseases[J]. J China Pharm Univ, 2024, 55(2): 194 − 201. DOI: 10.11665/j.issn.1000-5048.2023112302
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Research progress of integrated stress response in central nervous system diseases

  • New Drug Screening and Pharmacodynamics Evaluation Center, State Key Laboratory for Multi-target Natural Medicine, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 82073831，No.82372577)
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  • Received Date: November 22, 2023
    Graphical Abstract
    • Abstract

  • Integrated stress response is an adaptive response produced by eukaryotic cells after intracellular and extracellular stimulation. The activation of integrated stress response inhibits the translation of most proteins, yet it can promote the translation of certain proteins to cope with complex cellular microenvironment changes. A large number of studies have found that in a variety of nervous system diseases, the integrated stress response can be activated by stress signals of disease-related cells and participates in the occurrence and progression of diseases through processes such as learning and memory consolidation, myelin regeneration and synaptic plasticity. This article summarizes the role, mechanism and possible drug targets of integrated stress response in central nervous system diseases and discusses the potential of pharmacological methods to regulate integrated stress response in the treatment of central nervous system diseases, in order to provide reference for pathological research on and drug development for central nervous system diseases.

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