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Mao Fengfei, Tu Xide, Zhu Jiabi, Zhao Lvhua, Shen Ganming, Fei Lipu, Fan Biting. ABSORPTION OF BAICALIN IN HUMAN[J]. Journal of China Pharmaceutical University, 1983, (1): 61-66.
Citation: Mao Fengfei, Tu Xide, Zhu Jiabi, Zhao Lvhua, Shen Ganming, Fei Lipu, Fan Biting. ABSORPTION OF BAICALIN IN HUMAN[J]. Journal of China Pharmaceutical University, 1983, (1): 61-66.
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ABSORPTION OF BAICALIN IN HUMAN

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  • Injections, tablets and solution of baicalin were given to each normal healthyman for the study of their absorption. The baicalin in urine was separated by ch-romatography and determined by UV spectrophotometric method. The pharmacokinetic data were fitted by nonlinear least square method with pocket-computer. The result showed that the rate peak value of baicalin injection appeared in urine at 0.4hr (Bioavailability : 89.3%), while that of tablets or solution was between 7.5-16.5 hrs ( Bioavailability: 22-36%) . The mean half-life Of baicalin injection ( 1M ) was 0.62 hr. It is eliminated rapidly and thus the dose of intramuscular injection given once a day was unreasonable.
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