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In vitro stability of paclitaxel and docetaxel binary-drug loaded micelles[J]. Journal of China Pharmaceutical University, 2010, 41(5): 428-434.
Citation: In vitro stability of paclitaxel and docetaxel binary-drug loaded micelles[J]. Journal of China Pharmaceutical University, 2010, 41(5): 428-434.

In vitro stability of paclitaxel and docetaxel binary-drug loaded micelles

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  • The binary-drug loaded micelles(BDM),in which paclitaxel(PTX) and docetaxel(DTX) co-solubilized with the monomethoxy poly(ethylene glycol)-block-poly(D,L-lactide)(mPEG-PLA) copolymer,were prepared and evaluated for their in vitro stability.It was found that the stabilities of paclitaxel and docetaxel single-drug loaded micelles(SDM) with a drug-loading content of 10% maintained in the period of 9 h and 1 h,respectively,whereas the stable period of BDM with both drug-loading content of 25% was up to 24 h.Moreover,the BDM showed better physical stability at high drug concentration(≥1 mg/mL) than low concentration(0.04 mg/mL).In addition,a network structure of the BDM was observed using transmission electron microscopy(TEM).Faster in vitro release of paclitaxel and/or docetaxel from the BDM was found if compared with those of SDM.BDM in the potentials such as high drug-loading content and excellent stability might be an alternative to the micelles design.
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