• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
SHENG Shu-dong, YU You-jiang, WANG Dong-yan, QIAN Xiao-mei, XIAO Wang-shu. Inhibition of Hainan holly leaf extract on rats with experimental benign prostatic hyperplasia[J]. Journal of China Pharmaceutical University, 2011, 42(6): 551-554.
Citation: SHENG Shu-dong, YU You-jiang, WANG Dong-yan, QIAN Xiao-mei, XIAO Wang-shu. Inhibition of Hainan holly leaf extract on rats with experimental benign prostatic hyperplasia[J]. Journal of China Pharmaceutical University, 2011, 42(6): 551-554.

Inhibition of Hainan holly leaf extract on rats with experimental benign prostatic hyperplasia

More Information
  • 48 rats were randomly divided into 6 groups:a normal control group,a model group of benign prostatic hyperplasia(BPH) treated by subcutaneous injection of testosterone propionate,a positive control group (rat in model group treated with Qianliekang by orally) and Hainan holy leaf extract (HHLE) groups (rat in model group treated with HHLE by orally).After treating 5 weeks,the rat prostate wet weight,the index of prostate gland(PI),the serum acid phosphatase (ACP),non-prostate-specific acid phosphatase (NPAP) and PAP were measured.Morphological changes of the prostate tissue under optical microscope were observed.Results showed that prostate wet weight,PI and serum PAP of high and medium dose groups were obviously decreased compared with the model group,with a significant difference (P<0.01) similar to that of Qianliekang.High-doses group (80 mg/kg) improved the morphological changes of the prostate characterized by reducing interstitial fibrosis,increasing secretions in the glandular cavity and prostate calculi showing eosinophilic,which were similar to those of the normal group.HHLE has inhibitive effect on BPH induced by testosterone propionate in rats.
  • Related Articles

    [1]XU Tao, WANG Xiaowei, LIU Xiaorong, WANG Yazhou, LI Zhiyu. Design, synthesis and biological evaluation of ALK5 inhibitors[J]. Journal of China Pharmaceutical University, 2020, 51(4): 441-448. DOI: 10.11665/j.issn.1000-5048.20200408
    [2]WANG Lei, MA Jun, GU Mengyue, DI Rongrong, LIU Yu, LAI Yisheng. Design, synthesis and biological evaluation of five-membered heterocyclopyrimidines as MTH1 inhibitors[J]. Journal of China Pharmaceutical University, 2018, 49(4): 407-412. DOI: 10.11665/j.issn.1000-5048.20180404
    [3]JIN Shuanglong, WANG Fang, ZOU Yi, WANG Yan, HU Yue, GUO Wenjie, XU Qiang, LAI Yisheng. Design, synthesis and biological evaluation of phenylsulfonamide-based IDO1 inhibitors[J]. Journal of China Pharmaceutical University, 2018, 49(1): 34-38. DOI: 10.11665/j.issn.1000-5048.20180105
    [4]ZHU Bao, JIN Shuanglong, GUO Yi, LI Yuezhen, ZHANG Yihua, LAI Yisheng. Design, synthesis and biological evaluation of pyridine-based IRAK4 inhibitors[J]. Journal of China Pharmaceutical University, 2017, 48(6): 670-674. DOI: 10.11665/j.issn.1000-5048.20170606
    [5]LI Jing, JIN Xiaoting, ZHANG Liying. Synthesis and biological evaluation of novel amide derivatives of pentacyclic triterterpenes as inhibitors of glycogen phosphorylase[J]. Journal of China Pharmaceutical University, 2016, 47(4): 422-428. DOI: 10.11665/j.issn.1000-5048.20160406
    [6]LI Hui, YANG Lingyun, ZHOU Jinpei, ZHANG Huibin. Synthesis and evaluation of oxazolidinone ether compounds as factor Xa inhibitors[J]. Journal of China Pharmaceutical University, 2013, 44(5): 385-389. DOI: 10.11665/j.issn.1000-5048.20130501
    [7]WU Mingming, FANG Lei, GOU Shaohua, CHEN Li. 以2-甲基-2-取代苯氧基丙酸为离去基团的铂(Ⅱ)配合物的合成、表征及细胞毒活性[J]. Journal of China Pharmaceutical University, 2013, 44(4): 303-306. DOI: 10.11665/j.issn.1000-5048.20130403
    [8]ZHAO Lu-ya, CHEN Li, REN Yu, SU Guo-qiang. Synthesis and in vitroactivity of DPP-IV inhibitor analogues containing piperazine[J]. Journal of China Pharmaceutical University, 2012, 43(3): 204-208.
    [9]WANG Yu-bin, ZHANG Hui-bin, QIAN Hai, HUANG Wen-long. Synthesis and biological evaluation of 2-azetidinone derivatives as cholesterol absorption inhibitors[J]. Journal of China Pharmaceutical University, 2011, 42(3): 213-219.
    [10]Synthesis and Bioactivity of N,N''''-Bis-substituted Urea Derivatives as Novel Small Molecular Inhibitors of Cysteine Protease of Trypanosoma cruzi[J]. Journal of China Pharmaceutical University, 2003, (6): 10-14.

Catalog

    Article views (1234) PDF downloads (1883) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return