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CHU Xiaojing, ZHANG Ying, QIAO Chunhua, AO Guizhen, YANG Shengwei, DONG Yan. Synthesis and anti-tumor activity of rhodanine derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(2): 113-116. DOI: 10.11665/j.issn.1000-5048.20130203
Citation: CHU Xiaojing, ZHANG Ying, QIAO Chunhua, AO Guizhen, YANG Shengwei, DONG Yan. Synthesis and anti-tumor activity of rhodanine derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(2): 113-116. DOI: 10.11665/j.issn.1000-5048.20130203

Synthesis and anti-tumor activity of rhodanine derivatives

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  • Based on the study of rhodanine derivative WL-276,some novel compounds were synthesized,and their anti-tumor effects were screened by MTT method.Compounds II1-4 were obtained by cyclization and condensation from the certain amino acids,and then coupled respectively with hydrogen sulfide donor ADT-OH to afford compounds III1-4,whose structures were confirmed by 1H NMR,IR and HR MS.Furthermore,preliminary pharmacological results suggested that compounds II1,3,4,III1-4 had strong inhibitory effects on the proliferation of HepG2 and DU145 tumor cells.Particularly,the anti-proliferation activity of compounds III2,4 on HepG2 and compounds III1,2,4 on DU145 tumor cells was stronger than that of the positive control,5-fluorouracil.
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