Advanced Search
MA Xiaoping, XU Ying, DING Jie, LIN Na. Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 341-345. DOI: 10.11665/j.issn.1000-5048.20140316
Citation: MA Xiaoping, XU Ying, DING Jie, LIN Na. Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 341-345. DOI: 10.11665/j.issn.1000-5048.20140316
shu

Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats

More Information
    Graphical Abstract
    • Abstract
  • The objective of this study was to evaluate the effects of estradiol valerate(EV)on the estrogen receptor expression and the pathological changes of tissues in uterus, vagina and breast of ovariectomized rats, and investigate the estrogen-like mechanism. HE method was used to determine the tissue pathological changes; the protein expression levels of estrogen receptor alpha(ERα)and estrogen receptor beta(ERβ)in mammary gland, uterus and vagina were detected by immunohistochemistry and Western blot. The results indicated that estradiol valerate could obviously antagonize the atrophy of the target organs in ovariectomized rats, and the up-regulated expression of the estrogen receptors in target organs is the possible mechanism of EV induced estrogenic activity.
    • FullText(HTML)
    • References (12)
  • [1]
    Teichmann A.Pharmacology of estradiol valerate/dienogest[J].Climacteric,2003,6(Suppl 2):17-23.
    [2]
    Blode H,Zeun S,Parke S,et al.Evaluation of the effects of rifampicin,ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women[J].Contraception,2012,86(4):337-344.
    [3]
    Noorafshan A,Ahmadi M,Mesbah SF,et al.Stereological study of the effects of letrozole and estradiol valerate treatment on the ovary of rats[J].Clin Exp Reprod Med,2013,40(3):115-112.
    [4]
    Rafie S,Borgelt L,Koepf ER,et al.Novel oral contraceptive for heavy menstrual bleeding:estradiol valerate and dienogest[J].Int J Womens Health,2013,5:313-321.
    [5]
    Wiegratz I,Lee JH,Kutschera E,et al.Effect of four oral contraceptives on hemostatic parameters[J].Contraception,2004,70(2):97-106.
    [6]
    Brawer JR,Munoz M,Farookhi R.Development of the polycystic ovarian condition(PCO)in the estradiol valerate-treated rat[J].Biol Reprod,1986,35(3):647-655.
    [7]
    Shi D,Vine DF.Animal models of polycystic ovary syndrome:a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk[J].Fertil Steril,2012,98(1):185-193.
    [8]
    Yuan BJ,Wang QZ.Preclinical Safety Evaluation of New Drugs and Practice[M].Beijing:Military Medical Science Press,1997:125-136.
    [9]
    Lin H,Zang W,Zheng YL,et al.Early pregnancy supplement for male offspring rats estradiol valerate affect the reproductive system development[J].Natl J Androl(中华男科学杂志),2009, 15(9):779-782.
    [10]
    Couse JF,Korach KS.Reproductive phenotypes in the estrogen receptor-alpha knockout mouse[J].Ann Endocrinol(Paris),1999,60(2):143-148.
    [11]
    Hewitt SC,Korach KS.Oestrogen receptor knockout mice:roles for oestrogen receptors alpha and beta in reproductive tissues[J].Reproduction,2003,125(2):143-149.
    [12]
    Rimoldi G,Christoffel J.Effects of chronic genistein treatment in mammary gland,uterus,and vagina[J].Environ Health Perspect,2007,115(Suppl 1):62-68.
    • Related Articles

  • Related Articles

    [1]LAI Xingzhao, FAN Lingling, HUANG Suqing, HUANG Congcong, LI Jian, TAN Ninghua. Effects and mechanism of Mailuoning oral liquid on arteriosclerosis occlusion in vitro[J]. Journal of China Pharmaceutical University, 2025, 56(1): 91-98. DOI: 10.11665/j.issn.1000-5048.2024070201
    [2]SU Boya, XU Yuansheng, WANG Hua, TANG Yuqing, ZHANG Shiqun, SONG Yan. Progress of research on disease-modifying osteoarthritis drugs[J]. Journal of China Pharmaceutical University, 2021, 52(2): 253-260. DOI: 10.11665/j.issn.1000-5048.20210215
    [3]FAN Wenxiang. Research progress on the mechanism of ischemic stroke[J]. Journal of China Pharmaceutical University, 2018, 49(6): 751-759. DOI: 10.11665/j.issn.1000-5048.20180618
    [4]SHAO Hua, SONG Yifan, HE Jie, HU Linlin. Pharmacokinetics and drug concentration monitoring of high-dose tigecycline in patients with septic shock[J]. Journal of China Pharmaceutical University, 2017, 48(6): 721-726. DOI: 10.11665/j.issn.1000-5048.20170614
    [5]ZHA Zhengqi, CHEN Qiuli, WANG Yufeng, ZHU Hui, WANG Ying, YIN Hongping, YUE Long. Protective effects of Cordyceps sinensis polysaccharide CPS-A on angiotensin II-induced injury of liver L02 cells[J]. Journal of China Pharmaceutical University, 2017, 48(4): 490-495. DOI: 10.11665/j.issn.1000-5048.20170415
    [6]YANG Ruocong, DUAN Feipeng, CHAO Jiahong, TIAN Pengpeng, YAN Zhiyong, LI Shaojing. Advances of microRNA activity in innate immunity[J]. Journal of China Pharmaceutical University, 2017, 48(4): 396-406. DOI: 10.11665/j.issn.1000-5048.20170403
    [7]LIU Hui, JI Xu. P2X7 receptor and renal diseases[J]. Journal of China Pharmaceutical University, 2015, 46(5): 629-634. DOI: 10.11665/j.issn.1000-5048.20150519
    [8]WANG Tao, ZHOU Zhixing, LIU Wei, JIANG Zhenzhou, ZHAO Guolin, SHANG Jing, ZHANG Luyong. Effects of colchicine on cholestatic liver injury in rats induced by bile duct ligation[J]. Journal of China Pharmaceutical University, 2014, 45(6): 715-719. DOI: 10.11665/j.issn.1000-5048.20140618
    [9]Non-traditional antiarrhythmic medicines for atrial fibrillation[J]. Journal of China Pharmaceutical University, 2010, 41(1): 86-90.
    [10]Effects of Herbs-Electrothermic Pad on Experimental Ankle Joint Inflammation of Rats[J]. Journal of China Pharmaceutical University, 1991, (6): 381-382.

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：436315

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return