• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
YE Lianbao, WU Jieyu, YANG Jiebo, LUO Jiaoyan, HU Qiaohong. Synthesis of the related substances of gefitinib[J]. Journal of China Pharmaceutical University, 2014, 45(6): 667-670. DOI: 10.11665/j.issn.1000-5048.20140608
Citation: YE Lianbao, WU Jieyu, YANG Jiebo, LUO Jiaoyan, HU Qiaohong. Synthesis of the related substances of gefitinib[J]. Journal of China Pharmaceutical University, 2014, 45(6): 667-670. DOI: 10.11665/j.issn.1000-5048.20140608
shu

Synthesis of the related substances of gefitinib

More Information
    Graphical Abstract
    • Abstract
  • To strengthen the quality control over gefitinib and establish its quality criterion, four related substances of gefitinib were identified based on the synthetic route and synthesized, and their structures were confirmed by 1H NMR and MS. These substances were 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol( A ), N-(3-chloro-4-fluorophenyl)-6, 7-dimethoxyquinazolin-4-amine( B ), 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)propylamino)ethanol( C )and N-(3, 4-dichlorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine( D ).
    • FullText(HTML)
    • References (8)
  • [1]
    AstraZeneca plc(GB).Oncolytic EGF receptor tyrosine kinase inhibitor IressaTM[J].Drugs Future,2002,27(4):339-345.
    [2]
    Zhang H,Zhao JH,Wang H.Synthesis of 4-(3-chloro-4-fluoro-phenylamineo)-7-methoxy- 6-(3-morpholin-4-yl-propoxy)-quinazoline: CN,200810122242.2[P].2009-04-08.
    [3]
    Lv TJ,Ouyang QP,Meng XB,et al.Synthesis of gefitinib[J].Guangzhou Chem Ind(广州化工),2010,38(12):154-156.
    [4]
    Xi YY,Zhang QW.Synthesis of gefitinib[J].Chin J Pharm(中国医药工业杂志),2008,39(6):401-403.
    [5]
    Xie LH, Ouyang GP. Process Improvement on the synthesis of gefitinib[J].Chin J Synth Chem(合成化学),2010,18(4):523-525.
    [6]
    Xiao HL,Wang P,Wang YJ,et al.Improved synthesis of gefitinib[J].J Ocean Univ China(中国海洋大学学报),2010,40(8):103-106.
    [7]
    Jin B,Chen GH,Zhou AF,et al.Synthesis of gefitinib[J].J China Pharm Univ(中国药科大学学报),2005,36(1):92-94.
    [8]
    Li XS, Zhang AQ, Huang L. Process for the preparation of gefitinib:CN,200910192850.5[P].2009-09-30.
    • Related Articles

  • Related Articles

    [1]GUO Wei, XIE Chunwen, WANG Wensheng, ZHENG Deqiang, HE Shuwang. Synthesis of related substances of tebipenem pivoxil[J]. Journal of China Pharmaceutical University, 2018, 49(3): 286-290. DOI: 10.11665/j.issn.1000-5048.20180305
    [2]LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306
    [3]YUAN Duo, ZHU Xiong, ZHANG Shijin, WANG Duo, LI Zhiyu, SUN Liping. Analysis and synthesis of the related substances of palbociclib[J]. Journal of China Pharmaceutical University, 2015, 46(6): 696-699. DOI: 10.11665/j.issn.1000-5048.20150610
    [4]ZHANG Changqing, FAN Rong, WANG Feng. Synthesis of two related substances of everolimus[J]. Journal of China Pharmaceutical University, 2015, 46(2): 174-177. DOI: 10.11665/j.issn.1000-5048.20150206
    [5]WU Mingming, FANG Lei, GOU Shaohua, CHEN Li. 以2-甲基-2-取代苯氧基丙酸为离去基团的铂(Ⅱ)配合物的合成、表征及细胞毒活性[J]. Journal of China Pharmaceutical University, 2013, 44(4): 303-306. DOI: 10.11665/j.issn.1000-5048.20130403
    [6]Synthesis of Terbinafine[J]. Journal of China Pharmaceutical University, 2001, (1): 10-11.
    [7]Synthesis of Dopexamine[J]. Journal of China Pharmaceutical University, 1999, (5): 328-331.
    [8]The Synthesis of Ba m buterol[J]. Journal of China Pharmaceutical University, 1999, (4): 11-12.
    [9]Synthesis of Oxendolone[J]. Journal of China Pharmaceutical University, 1997, (5): 8-11.
    [10]Synthesis of Milrinone[J]. Journal of China Pharmaceutical University, 1996, (6): 59-60.

Catalog

    Get Citation
    PDF
    XML
    Article views (1912) PDF downloads (1721) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：415019

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return