Optimization and validation of the analytical methods to detect common illicit drugs in sewage

WANG Ye; XU Lei; XU Peng; HANG Taijun; SONG Min; WANG Youmei; XU Hui

doi:10.11665/j.issn.1000-5048.20220409

Journal of China Pharmaceutical University > 2022 > 53(4): 467-472. > DOI: 10.11665/j.issn.1000-5048.20220409

WANG Ye, XU Lei, XU Peng, HANG Taijun, SONG Min, WANG Youmei, XU Hui. Optimization and validation of the analytical methods to detect common illicit drugs in sewage[J]. Journal of China Pharmaceutical University, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409

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Optimization and validation of the analytical methods to detect common illicit drugs in sewage

WANG Ye^1,2,
XU Lei^1,2,
XU Peng^2,3,
HANG Taijun^1,2,
SONG Min^1,2,
WANG Youmei^2,3,
XU Hui^1,2

1.
School of Pharmacy, China Pharmaceutical University, Nanjing 210009
2.
Office of China National Narcotics Control Commission China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Nanjing 210009
3.
Drug Control Information and Technology Center of Ministry of Public Security of the People's Republic of China, Beijing 100741, China

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Received Date: November 10, 2021
Revised Date: June 01, 2022

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Abstract

Abstract

The waste water-based epidemiology is an important technique to fight against drug abuse by analyzing the concentration of illicit drugs in urban sewage, which can monitor the abuse of drugs.An SPE-UPLC-MS/MS method was developed for the analysis of 12 common drugs and their metabolites involving amphetamine and morphine.It was shown that the best result was achieved when hydrochloric acid/ acetonitrile (5∶95) was added to acidify the sample during the concentration process, guaranteeing the anti-across contamination of the analysis of organic nitrogen basic trace components, and improve the stability, specificity, and accuracy of the method.The optimized method meets the analytical requirements of complex sewage samples, and has been successfully applied to the assessment of urban drug abuse through sewage analysis.
- drug analysis,
- sewage-based epidemiology,
- SPE-UPLC-MS/MS,
- solid phase extraction

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References (28)

References

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