• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
XIONG Xiao-ying, LI Juan. Studies on the microemulsion-based hydrogel formulation of ketoprofen and the transdermal mechanism[J]. Journal of China Pharmaceutical University, 2012, 43(6): 514-518.
Citation: XIONG Xiao-ying, LI Juan. Studies on the microemulsion-based hydrogel formulation of ketoprofen and the transdermal mechanism[J]. Journal of China Pharmaceutical University, 2012, 43(6): 514-518.

Studies on the microemulsion-based hydrogel formulation of ketoprofen and the transdermal mechanism

More Information
  • This study was to prepare ketoprofen loaded microemulsion-based hydrogel(MBH) and investigate its transdermal mechanism.The pseudo-ternary phase diagrams for O/W microemulsion regions were constructed.Various microemulsion formulations were prepared and the abilities of various microemulsions to deliver ketoprofen through the skin were evaluated in vitro using Franz diffusion cells fitted with mouse skins.The data showed that the drug in microemulsions/MBH resorted in skin (705.13±33.18) and (502.75±28.54) μg/cm2,which were 4.66 and 3.22 times the control group.The DSC and HE studies showed that microemulsion/MBH affected the normal lipid packing of stratum corneum to enhance the drug permeation.Coumarin-6 labeled preparation were mainly distributed in the stratum corneum and hair follicle.
  • Related Articles

    [1]SHI Xiaoni, YANG Shaoqi, CHENG Yusi, CHAO Jie. PPP2R3A promotes silicosis by regulating the expression of p53[J]. Journal of China Pharmaceutical University, 2022, 53(4): 490-497. DOI: 10.11665/j.issn.1000-5048.20220412
    [2]CHEN Suting, CHEN Song, GAO Xiangdong. Construction, expression, purification and neuroprotective activity of TAT-FGF21 fusion protein[J]. Journal of China Pharmaceutical University, 2018, 49(4): 496-501. DOI: 10.11665/j.issn.1000-5048.20180417
    [3]WANG Chi, TIAN Hong, GAO Xiangdong, YAO Wenbing. Influence of ubiquitous chromatin opening element on the antibody expression in CHO cells[J]. Journal of China Pharmaceutical University, 2017, 48(1): 96-101. DOI: 10.11665/j.issn.1000-5048.20170115
    [4]PENG Chen, GE Hao, HE Shu-ying, GAO Xiang-dong. Molecular cloning,expression and identification of recombinant hyaluronan synthase from Pasteurella multocida[J]. Journal of China Pharmaceutical University, 2009, 40(6): 549-552.
    [5]Cloning of UreB from Helicobacter pylor and Its Expression in E.coli[J]. Journal of China Pharmaceutical University, 2004, (2): 86-89.
    [6]Expression of Human Transforming Growth Factor β3 in E.coli BL21[J]. Journal of China Pharmaceutical University, 2003, (3): 70-73.
    [7]Cloning of S-adenosyl-L-methionine Synthetase Gene from Saccharomyces ceverisiae and its Expression in E.coli[J]. Journal of China Pharmaceutical University, 2002, (3): 87-89.
    [8]Cloning of D-hydantoinaseGene from Pseudomonas and Its Expression in E.coli[J]. Journal of China Pharmaceutical University, 2001, (3): 69-72.
    [9]Molecular Cloning and Expression of S-Adenosylmethionine Synthetase Gene of Escherichia coli[J]. Journal of China Pharmaceutical University, 2000, (6): 70-73.
    [10]The Construction of an E.coli Strain with Expression of Fumarate Hydratase[J]. Journal of China Pharmaceutical University, 1994, (3): 159-162.
  • Cited by

    Periodical cited type(1)

    1. 凌珍,张洁,黄艳琴,张敏,韦理莎,罗佳媛,何林洪. 选择性JAK2&JAK3双重抑制剂的设计和合成. 化学试剂. 2025(04): 105-111 .

    Other cited types(0)

Catalog

    Article views (1387) PDF downloads (2833) Cited by(1)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return