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伊犁贝母总生物碱的药效学研究[J]. 中国药科大学学报, 2003, (2): 76-80.
引用本文: 伊犁贝母总生物碱的药效学研究[J]. 中国药科大学学报, 2003, (2): 76-80.
Studies on the Pharmacodynamics of the Crude Alkaloids from Fritillaria pallidiflora Schrenk[J]. Journal of China Pharmaceutical University, 2003, (2): 76-80.
Citation: Studies on the Pharmacodynamics of the Crude Alkaloids from Fritillaria pallidiflora Schrenk[J]. Journal of China Pharmaceutical University, 2003, (2): 76-80.

伊犁贝母总生物碱的药效学研究

Studies on the Pharmacodynamics of the Crude Alkaloids from Fritillaria pallidiflora Schrenk

  • 摘要: 目的:研究伊犁贝母总生物碱的镇咳、祛痰和平喘作用。方法:以小鼠氨水引咳法、豚鼠枸檬酸引咳法和猫喉上神经刺激引咳法观察其镇咳作用;以小鼠酚红排泌法、大鼠毛细管排痰法观察其祛痰作用;以豚鼠乙酰胆碱—组胺引喘法观察其平喘作用。结果:在10mg/kg剂量下,十二指肠给药对电刺激猫喉上神经引咳具有显著的镇咳作用。连续灌胃给药5d,伊犁贝母总生物碱在40,20,10mg/kg的剂量下对小鼠氨水引咳具有显著的镇咳作用;在20,10mg/kg的剂量下对豚鼠枸檬酸引咳具有显著的镇咳作用,能显著增加大鼠毛细管排痰量;在40,20mg/kg的剂量下具有显著增加小鼠酚红排泌量的作用,对乙酰胆碱-组胺所致的豚鼠哮喘具有显著的平喘作用。结论:伊犁贝母总生物碱对实验动物具有显著的镇咳、祛痰及平喘作用。

     

    Abstract: The purpose is to study the phar macodynamics o f the crude alkaloids from Fritillaria pallidiflora Schrenk(FPA). The antitussive activities of the crude alkaloids were invest igated th rough testing the cough times induced by ammonium hydroxide in m

     

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