• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
NI Xiaojia, HU Haitang, ZHANG Ming, HU Jinqing, SHANG Dewei, WEN Yuguan. Pharmacokinetics of blonanserin tablets in Chinese healthy volunteers[J]. Journal of China Pharmaceutical University, 2013, 44(6): 540-542. DOI: 10.11665/j.issn.1000-5048.20130610
Citation: NI Xiaojia, HU Haitang, ZHANG Ming, HU Jinqing, SHANG Dewei, WEN Yuguan. Pharmacokinetics of blonanserin tablets in Chinese healthy volunteers[J]. Journal of China Pharmaceutical University, 2013, 44(6): 540-542. DOI: 10.11665/j.issn.1000-5048.20130610
shu

Pharmacokinetics of blonanserin tablets in Chinese healthy volunteers

More Information
    Graphical Abstract
    • Abstract
  • To study the pharmacokinetics of blonanserin tablets in thirty Chinese healthy volunteers grouped into three single-dose levels of 4, 8 and 12 mg. The blood samples were collected up to 60 h after oral administration. The plasma concentration of blonanserin was determined by a validated LC-MS/MS method. The pharmacokinetic parameters were calculated by DAS 3. 2. 4 software. The main pharmacokinetic parameters of blonanserin after the single dose of 4, 8 and 12 mg were as follows: cmax were(539. 61±388. 74), (1 190. 39±736. 51)and(1 637. 34±481. 45)ng/L; tmax were(1. 00±0. 47), (1. 38 ±0. 79)and(1. 43±0. 94)h; t1/2 were(12. 05±3. 49), (14. 76±3. 78)and(13. 68±3. 92)h; AUC0-60 h were(4 692. 21±3 041. 75), (7 964. 42±3 988. 07)and(9 648. 22±2 565. 07)ng ·h/L; AUC0-∞ were(5 060. 91±3 146. 10), (8 547. 61±4 209. 87)and(9 986. 15±2 659. 51)ng ·h/L, respectively. The main pharmacokinetic parameters of blonanserin positively correlated with the dose over the range of 4-12 mg.
    • FullText(HTML)
    • References (4)
  • [1]
    Chang MH,Li YH.A new antipsychotic agent:blonanserin[J].Chin J New Drugs Clin Rem(中国新药与临床杂志),2010(29):571-575.
    [2]
    Wen YG,Ni XJ,Zhang M,et al.Simultaneous determination of blonanserin and its metabolite in human plasma and urine by liquid chromatography-tandem mass spectrometry:application to a pharmacokinetic study[J].J Chromatogr B Analyt Technol Biomed Life Sci,2012,903(15):46-52.
    [3]
    Suzuki H,Gen K.The relationship between the plasma concentration of blonanserin,and its plasma anti-serotonin 5-HT(2A)activity/anti-dopamine D2 activity ratio and drug-induced extrapyramidal symptoms[J].Psychiatry Clin Neurosci,2012,66(2):146-152.
    [4]
    Saruwatari J,Yasui-Furukori N,Inoue Y,et al.Effect of dose timing in relation to food intake on systemic exposure to blonanserin[J].Eur J Clin Pharmacol,2010,66(9):899-902.
    • Related Articles

  • Related Articles

    [1]ZHANG Huili, LU Guangli, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activity of pefloxacin C-3 methylene rhodanine devatives[J]. Journal of China Pharmaceutical University, 2019, 50(6): 672-677. DOI: 10.11665/j.issn.1000-5048.20190606
    [2]ZHANG Huili, LI Ke, ZHAO Hui, HU Guoqiang, HUANG Wenlong. Synthesis and antitumor activity of fluoroquinolone C-3 s-triazole Schiff-base carboxylic acid derivatives from pefloxacin(X)[J]. Journal of China Pharmaceutical University, 2017, 48(2): 167-171. DOI: 10.11665/j.issn.1000-5048.20170206
    [3]XIE Yusuo, GAO Liuzhou, YAN Qiang, WU Shumin, NI Lili, HUANG Wenlong, ZHAO Hui, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(VIII):s-triazole sulfide-one thiosemicarbazone derivatives from pefloxacin[J]. Journal of China Pharmaceutical University, 2015, 46(4): 416-420. DOI: 10.11665/j.issn.1000-5048.20150405
    [4]QIAO Yixue, MOU Yi, HUANG Zhangjian, AI Yong, KANG Fenghua, LAI Yisheng, ZHANG Yihua. Synthesis and antitumor activities of novel CDDO-Me analogues[J]. Journal of China Pharmaceutical University, 2015, 46(3): 289-293. DOI: 10.11665/j.issn.1000-5048.20150305
    [5]CHEN Shumin, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(VI):s-triazole-acylhydrazone methylsulfide derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(5): 511-516. DOI: 10.11665/j.issn.1000-5048.20140501
    [6]CHEN Shumin, HUANG Wenlong, HU Guoqiang. Synthesis and antitumor activity of fluoroquinolone C-3 isostere V: ciprofloxacin acylhydrazone derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(2): 161-164. DOI: 10.11665/j.issn.1000-5048.20140205
    [7]SUN Yusheng, XU Qiuju, HOU Lili, YUE Xibo, WU Zhaofeng, HUANG Wenlong, XIE Songqiang, HU Guoqiang. Synthesis and antitumor activities of fluoroquinolone C-3 isosteres(IV):s-triazole-oxadiazole methylsulfide Mannich-base derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(1): 39-42. DOI: 10.11665/j.issn.1000-5048.20140106
    [8]HU Kun, ZHOU Anfei, JIANG Hefei, XU Yuanyuan, HUANG Qianhui, YANG Jie, CHEN Xin, REN Jie. Synthesis and antitumor activities of podophyllotoxin derivatives[J]. Journal of China Pharmaceutical University, 2014, 45(1): 33-38. DOI: 10.11665/j.issn.1000-5048.20140105
    [9]XU Qiuju, HOU Lili, WU Xiaokui, XIE Songqiang, HU Guoqiang, HUANG Wenlong. Synthesis and antitumor activity of ciprofloquinolone bis-(C3/C7 hydrazone)s[J]. Journal of China Pharmaceutical University, 2013, 44(1): 35-38. DOI: 10.11665/j.issn.1000-5048.20130105
    [10]HU Guo-qiang, HOU Li-li, WANG Guo-qiang, DUAN Nan-nan, WEN Xiao-yi, CAO Tie-yao, HUANG Wen-long. Synthesis and antitumor and antibacterial activities of fluoroquinolone C-3 isosteres I.norfloxacin C-3 carbonylhydrazone derivatives[J]. Journal of China Pharmaceutical University, 2012, 43(4): 298-301.

Catalog

    Get Citation
    PDF
    XML
    Article views (1275) PDF downloads (1768) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：297216

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return