Antibacterial activity of 10 phenolic compounds from mulberry

PANG Daorui; LIU Fan; SHI Ying; LIU Jun; SHEN Weizhi; ZOU Yuxiao; LIAO Sentai; XIAO Gengsheng

doi:10.11665/j.issn.1000-5048.20140216

Journal of China Pharmaceutical University > 2014 > 45(2): 221-226. > DOI: 10.11665/j.issn.1000-5048.20140216

PANG Daorui, LIU Fan, SHI Ying, LIU Jun, SHEN Weizhi, ZOU Yuxiao, LIAO Sentai, XIAO Gengsheng. Antibacterial activity of 10 phenolic compounds from mulberry[J]. Journal of China Pharmaceutical University, 2014, 45(2): 221-226. DOI: 10.11665/j.issn.1000-5048.20140216

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Antibacterial activity of 10 phenolic compounds from mulberry

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Abstract

Inhibition zone diameters and minimum inhibitory concentrations(MIC)of 10 phenolic compounds from mulberry(Morus alba L. )against 4 common pathogenic bacteria(Staphyloccocus aureus, Bacillus subtilis, Escherichia coli, Salmonella spp )were tested by agar diffusion and micro-dilution in order to study the antibacterial activity of mulberry. The results indicated that the monomeric compounds exhibited more effect on Gram-positive bacteria(Staphylococcus aureus, Bacillus subtilis)than Gram-negative ones(E. coli, Salmonella). The antibacterial activity of Morusin, Kuwanon E and Sanggenol A on Gram-positive bacteria were the best. Especially, the MIC of Morusin against Bacillus subtilis was below 3. 72 μmol/L. Structure-activity relationships of these compounds were also discussed. It was found that stereoisomerism, species and position of substituent had implications for their antibacterial activity. Especially, prenyl was very important for the antibacterial activity of compounds.
- mulberry,
- phenolic compounds,
- antibacterial activity,
- structure-activity relationship

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[1]	Lv HS.Principles of Moricultural Science(栽桑学原理)[M].Shanghai:Shanghai Science and Technique Publishing House,2008:9-10.
[2]	Liao ST,Xiao GS.Study of active substance from mulberry(桑树活性物质研究)[M].Beijing:China agricultural science and technology Publishing House,2012,1:186-208.
[3]	Wang H,Wu S,Sun YF,et al.An assay on the antiviral activity of mulberry leaf extract[J].Sci Sericulture(蚕业科学),2011,37(5):952-956.
[4]	Zhou JY,Wang W,Zhou SW,et al.Advance on pharmacologic actions of medicament portions of mulberry[J].Chin J New Drugs Clin Rem(中国新药与临床杂志),2009,28(16):895-898.
[5]	Fan LS.Research on the antimierobial of Morus alba L,leaves[J].Nat Prod Res Dev(天然产物研究与开发),2001. 13:30-32.
[6]	Chen JJ,Liu F,Liao ST,et al.Study on antibacterial activity and stability of extracts from mulberry(Morus alba L.)leaves[J].Sci Technol Food Ind(食品工业科技),2012,33(9):88-91.
[7]	Chi XZ.Extraction,separation and analysis of antibacterial component from mulberry leaves(桑叶抑菌成分的提取分离及其分析)[D].Wuxi:Jiangnan University,2012.
[8]	Wang F, Li J, Jiang Y. Polysaccharides from mulberry leaf in relation to their antioxidant activity and antibacterial ability[J].J Food Process Eng,2010,33(1):39-50.
[9]	Qu C,Wang S.Macro-micro structure,antibacterial activity,and physico-mechanical properties of the mulberry bast fibers[J].Fiber Polym,2011,12(4):471-477.
[10]	Fukai T,Kaitou K,Terada S.Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus[J].Fitoterapia,2005,76(7):708-711.
[11]	Wan JH,Zhang XL,Xin SL.Antibacterial effect of Herba commelinae(Yazhical)[J].J Pub Health Prev Med(公共卫生与预防医学),2005,16(1):25-27.
[12]	Mathabe MC,Nikolova RV,Lall N,et al.Antibacterial activities of medicinal plants used for the treatment of diarrhoea in Limpopo Province,South Africa[J].J Ethnopharmacol,2006,105(1):286-293.
[13]	Amoo SO,Ndhlala AR,Finnie J F,et al.Antibacterial,antifungal and anti-inflammatory properties of Burchellia bubaline[J].South Afr J Bot,2009,75(1):60-63.
[14]	Wang HT.Anti-microoganism activity and anti-microbial mechanism of soybean isoflavone(大豆异黄酮的抑菌活性及其机制的研究)[D].Dalian:Liaoning Normal University,2009.
[15]	Li YN,Lv F,Liang H,et al.The antimicrobial activity of four essential oils and their stabilities[J].J Beijing Univ Chem Technol(Nat Sci)[北京化工大学学报(自然科学版)],2012,39(3):81-85.
[16]	Liu JH,Gao SL,Zhu DN,et al.Studies on antibaeterial activity of ampelopsin[J].J China Pharm Univ(中国药科大学学报),2002,33(5):439-441.
[17]	Jiang HX,Nie YX,Ji HW,et al. GC-MS analysis and antimicrobial activity study of essential oil from Perilla frutescens leaves[J].Chin Tradit Herb Drugs(中草药),2011,42(10):1 952-1 955.
[18]	Shen LX,Tashi Tsering,Geng YP,et al.Chemical constituents of essential oils from six artemisia species in Tibet and their Antibacterial activity[J].J Fudan Univ(复旦学报),2010,49(1):73-80.
[19]	López-Posadas R,Ballester I,Abadía-Molina AC,et al.Effect of flavonoids on rat splenocytes,a structure-activity relationship study[J].Biochem Pharmacol,2008,76(4):495-506.
[20]	Cholbi MR,Paya M,Alcaraz MJ.Inhibitory effects of phenolic compounds on CCl₄-induced microsomal lipid peroxidation[J].Experientia,1991,47(2):195-199.
[21]	Nowakowska Z,Kedzia B,Schroeder G.Synthesis,physicochemical properties and antimicrobial evaluation of new(E)-chalcones[J].Eur J Med Chem,2008,43(4):707-713.
[22]	Batovska D,Parushev S,Stamboliyska B,et al.Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted[J].Eur J Med Chem,2009,44(5):2 211-2 218.
[23]	Zou YS,Hou AJ,Zhu GF,et al.Cytotoxic isoprenylated xanthones from Cudrania tricuspidata[J].Bioorg Med Chem,2004,12(8):1 947-19 531.
[24]	Plochmann K,Korte G,Koutsilieri E,et al.Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells[J].Arch Biochem Biophys,2007,460(1):1-9.
[25]	Avila HP,Smania EFA,Monache FD,et al.Structure-activity relationship of antibacterial chalcones[J].Bioorg Med Chem,2008,16(22):9 790-9 794.
[26]	Li JK,He F,Bi HC,et al.Inhibition of human cytochrome P-450 CYP1A2 by flavonoids:a quantitative structure-activity relationship study[J].Acta Pharm Sin(药学学报),2008,43(12):1 198-1 204.

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