• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
YANG Huan, XIONG Jing, LUO Wenjing, XI Tao. Role of transcription factor DEC1 in the initiation and progression of malignant tumors[J]. Journal of China Pharmaceutical University, 2015, 46(5): 541-547. DOI: 10.11665/j.issn.1000-5048.20150504
Citation: YANG Huan, XIONG Jing, LUO Wenjing, XI Tao. Role of transcription factor DEC1 in the initiation and progression of malignant tumors[J]. Journal of China Pharmaceutical University, 2015, 46(5): 541-547. DOI: 10.11665/j.issn.1000-5048.20150504
shu

Role of transcription factor DEC1 in the initiation and progression of malignant tumors

More Information
    Graphical Abstract
    • Abstract
  • DEC1 is a basic helix-loop-helix(bHLH)transcription factor involved in the regulation of cell proliferation, cell differentiation, lymphocytes maturation, circadian rhythms, immune response and response to hypoxia. Recent studies have revealed that the expression of DEC1 is abnormally high in various tumor tissues and cells. In addition, the expression of DEC1 in the tumor tissue is related to the malignancy of various cancer types. This paper, therefore, focuses on the relationship between DEC1 and proliferation, apoptosis, cellular senescence, invasion and metastasis of tumor cells, in order to elaborate the role of DEC1 in the pathogenesis and progression of tumor.
    • FullText(HTML)
    • References (45)
  • [1]
    Shen M,Kawamoto T,Yan W,et al.Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in diffe-rentiated human embryo chondrocytes[J].Biochem Biophys Res Commun,1997,236(2):294-298.
    [2]
    Jinhua H,Zhao M,Wei S,et al.Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity[J].Curr Drug Targets,2014,15(4):432-441.
    [3]
    Miyazaki K,Miyazaki M,Guo Y,et al.The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells[J].J Immunol,2010,185(12):7330-7339.
    [4]
    Martinez-Llordella M,Esensten JH,Bailey-Bucktrout SL,et al.CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response[J].J Exp Med,2013,210(8):1603-1619.
    [5]
    Nakashima A,Kawamoto T,Honda KK,et al.DEC1 modulates the circadian phase of clock gene expression[J].Mol Cell Biol,2008,28(12):4080-4092.
    [6]
    Shen L,Cui A,Xue Y,et al.Hepatic differentiated embryo-chondrocyte-expressed gene 1(Dec1)inhibits sterol regulatory element-binding protein-1c(Srebp-1c)expression and alleviates fatty liver phenotype[J].J Biol Chem,2014,289(34):23332-23342.
    [7]
    Ivanova A,Liao SY,Lerman MI,et al.STRA13 expression and subcellular localisation in normal and tumour tissues:implications for use as a diagnostic and differentiation marker[J].J Med Genet,2005,42(7):565-576.
    [8]
    Teramoto M,Nakamasu K,Noshiro M,et al.Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2[J].J Biochem,2001,129(3):391-396.
    [9]
    Cho Y,Noshiro M,Choi M,et al.The basic helix-loop-helix proteins differentiated embryo chondrocyte(DEC)1 and DEC2 function as corepressors of retinoid X receptors[J].Mol Pharmacol,2009,76(6):1360-1369.
    [10]
    Noshiro M,Usui E,Kawamoto T,et al.Liver X receptors(LXRalpha and LXRbeta)are potent regulators for hepatic Dec1 expression[J].Genes Cells,2009,14(1):29-40.
    [11]
    Seuter S,Pehkonen P,Heikkinen S,et al.The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor[J].J Steroid Biochem Mol Biol,2013,136:62-67.
    [12]
    Turley H,Wykoff CC,Troup S,et al.The hypoxia-regulated transcription factor DEC1(Stra13,SHARP-2)and its expression in human tissues and tumours[J].J Pathol,2004,203(3):808-813.
    [13]
    Hu S,Shang W,Yue H,et al.Differentiated embryonic chondrocytes 1 expression of periodontal ligament tissue and gingival tissue in the patients with chronic periodontitis[J].Arch Oral Biol,2015,60(4):517-525.
    [14]
    Zheng Y,Jia Y,Wang Y,et al.The hypoxia-regulated transcription factor DEC1(Stra13,SHARP-2)and its expression in gastric cancer[J].OMICS,2009,13(4):301-306.
    [15]
    Zheng Y,Shi X,Wang M,et al.The increased expression of DEC1 gene is related to HIF-1alpha protein in gastric cancer cell lines[J].Mol Biol Rep,2012,39(4):4229-4236.
    [16]
    Ma W,Shi X,Lu S,et al.Hypoxia-induced overexpression of DEC1 is regulated by HIF-1alpha in hepatocellular carcinoma[J].Oncol Rep,2013,30(6):2957-2962.
    [17]
    Liu Y,Wang L,Lin XY,et al.The transcription factor DEC1(BHLHE40/STRA13/SHARP-2)is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells[J].Tumour Biol,2013,34(3):1641-1650.
    [18]
    Ehata S,Hanyu A,Hayashi M,et al.Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1[J].Cancer Res,2007,67(20):9694-9703.
    [19]
    Jia YF,Xiao DJ,Ma XL,et al.Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1alpha and Ki67 in human gastric cancer[J].Diagn Pathol,2013,8:37.
    [20]
    Miyazaki K,Kawamoto T,Tanimoto K,et al.Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes[J].J Biol Chem,2002,277(49):47014-47021.
    [21]
    Li Y,Bi Z,Yan B,et al.UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway[J].Int J Mol Med,2006,18(4):713-719.
    [22]
    Li Y,Bi Z.Ultravlolet-B induced expression of hypoxia-inducible factor 1alpha,transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway[J].Front Med China,2007,1(1):79-86.
    [23]
    Pan D,Li W,Miao H,et al.LW-214,a newly synthesized flavonoid,induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells[J].Biochem Pharmacol,2014,87(4):598-610.
    [24]
    Nishiwaki T,Daigo Y,Kawasoe T,et al.Isolation and mutational analysis of a novel human cDNA,DEC1(deleted in esophageal cancer 1),derived from the tumor suppressor locus in 9q32[J].Genes Chromosomes Cancer,2000,27(2):169-176.
    [25]
    Yang L,Leung AC,Ko JM,et al.Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma[J].Oncogene,2005,24(4):697-705.
    [26]
    Leung AC,Wong VC,Yang LC,et al.Frequent decreased expression of candidate tumor suppressor gene,DEC1,and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma[J].Int J Cancer,2008,122(3):587-594.
    [27]
    Su C,Zhang C,Tecle A,et al.Tudor staphylococcal nuclease(Tudor-SN),a novel regulator facilitating G1/S phase transition,acting as a co-activator of E2F-1 in cell cycle regulation[J].J Biol Chem,2015,290(11):7208-7220.
    [28]
    Wu Y,Sato F,Bhawal UK,et al.BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells[J].Biomed Res, 2012,33(2):75-82.
    [29]
    Qian Y,Zhang J,Jung YS,et al.DEC1 coordinates with HDAC8 to differentially regulate TAp73 and DeltaNp73 expression[J].PLoS One,2014,9(1):e84015.
    [30]
    Qian Y,Jung Y S,Chen X.DeltaNp63,a target of DEC1 and histone deacetylase 2,modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation[J].J Biol Chem,2011,286(14):12033-12041.
    [31]
    Li Y,Zhang H,Xie M,et al.Abundant expression of Dec1/stra13/sharp2 in colon carcinoma:its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation[J].Biochem J,2002,367(Pt 2):413-422.
    [32]
    Li Y,Xie M,Yang J,et al.The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter[J].Oncogene,2006,25(23):3296-3306.
    [33]
    Peng Y,Liu W,Xiong J,et al.Down regulation of differentiated embryonic chondrocytes 1(DEC1)is involved in 8-methoxypsoralen-induced apoptosis in HepG2 cells[J].Toxicology,2012,301(1/2/3):58-65.
    [34]
    Wu Y,Sato F,Bhawal UK,et al.Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells[J].Int J Mol Med,2011,27(4):491-495.
    [35]
    Stivarou T,Patsavoudi E.Extracellular molecules involved in cancer cell invasion[J].Cancers(Basel),2015,7(1):238-265.
    [36]
    Liu Y,Miao Y,Wang J,et al.DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1[J].Int J Mol Med,2013,31(4):855-860.
    [37]
    Cadenas C,van de Sandt L,Edlund K,et al.Loss of circadian clock gene expression is associated with tumor progression in breast cancer[J].Cell Cycle,2014,13(20):3282-3291.
    [38]
    Shi XH,Zheng Y,Sun Q,et al.DEC1 nuclear expression:a marker of differentiation grade in hepatocellular carcinoma[J].World J Gastroenterol,2011,17(15):2037-2043.
    [39]
    Kunimoto Y,Nakano S,Kataoka H,et al.Deleted in esophageal cancer 1(DEC1)is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines[J].ORL J Otorhinolaryngol Relat Spec,2011,73(1):17-23.
    [40]
    Wu Y,Sato F,Yamada T,et al.The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer[J].Int J Oncol,2012,41(4):1337-1346.
    [41]
    Collado M,Gil J,Efeyan A,et al.Tumour biology:senescence in premalignant tumours[J].Nature,2005,436(7051):642.
    [42]
    Qian Y,Zhang J,Yan B,et al.DEC1,a basic helix-loop-helix transcription factor and a novel target gene of the p53 family,mediates p53-dependent premature senescence[J].J Biol Chem,2008,283(5):2896-2905.
    [43]
    Xu Q, Ma P, Hu C, et al. Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma[J].PLoS One,2012,7(7):e41862.
    [44]
    Zhu Y,Xu L,Zhang J,et al.Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells[J].Cancer Sci,2013,104(8):1052-1061.
    [45]
    Kim YJ,Cha HJ,Nam KH,et al.Centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts[J].Exp Dermatol,2011,20(12):998-1003.
    • Related Articles

  • Related Articles

    [1]CHEN Xi, JIN Liang. Research progress on sumoylation in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2025, 56(1): 125-131. DOI: 10.11665/j.issn.1000-5048.2023112002
    [2]JIANG Xiaomei, LIU Chong. Neuroprotective effect of glycyrrhizin on diabetic retinopathy[J]. Journal of China Pharmaceutical University, 2020, 51(6): 711-717. DOI: 10.11665/j.issn.1000-5048.20200610
    [3]MU Jinming, LIU Yue, ZHANG Fangfang, JIN Liang. Relationship between circular RNA and type 2 diabetes and its clinical application[J]. Journal of China Pharmaceutical University, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316
    [4]TAO Yingjun, WU Jie, LIU Chang. Application of proteomics in diabetes and its complications[J]. Journal of China Pharmaceutical University, 2020, 51(3): 368-373. DOI: 10.11665/j.issn.1000-5048.20200315
    [5]YANG Xiaojun, AI Fengfeng, LIN Junbing, TANG Jiangjiang. Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity[J]. Journal of China Pharmaceutical University, 2019, 50(1): 41-45. DOI: 10.11665/j.issn.1000-5048.20190105
    [6]TANG Qian, CHEN Song, GAO Xiangdong. Advances of mechanisms of metabolic memory-based diabetic complications and therapeutic drugs[J]. Journal of China Pharmaceutical University, 2017, 48(5): 622-628. DOI: 10.11665/j.issn.1000-5048.20170519
    [7]HU Mengyue, LIU Can, ZHANG Mian, HU Nan, LIU Li, LIU Xiaodong. Alteration of cytochrome P450s activity under diabetic conditions and its impact on the development of diabetes mellitus[J]. Journal of China Pharmaceutical University, 2014, 45(2): 153-160. DOI: 10.11665/j.issn.1000-5048.20140204
    [8]WANG Xin-ting, ZHANG Mian, GUO Hai-fang, LIU Can, HU Nan, LIU Li, LIU Xiao-dong. Effect and mechanism of atorvastatin on blood glucose of mild diabetic rats[J]. Journal of China Pharmaceutical University, 2012, 43(5): 453-459.
    [9]XU Si-sheng, ZHANG Hui-bin, ZHOU Jin-pei, HUANG Jian-jun. Advances of new antidiabetic drugs[J]. Journal of China Pharmaceutical University, 2011, 42(2): 97-106.
    [10]PREVENTION AND TREATMENT OF ALLOXAN-INDUCED DIABETES IN MICE BY POLYSACCHARIDES FROM SPORE OF TREMELLA FUCIFORMIS BERK[J]. Journal of China Pharmaceutical University, 1988, (4): 303-304.

  • Cited by

    Periodical cited type(2)

    1. 林会平，孙国绍，梁波. 两种7-羟基香豆素衍生物的合成和NMR分析. 广州化学. 2020(01): 31-37 .
    2. 雷志伟，尹荣秀，李露露，郭灿. 香豆素类化合物合成的研究概况. 贵州茶叶. 2019(03): 18-21 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views (910) PDF downloads (2642) Cited by(4)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：302641

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return