Chemical constituents from the leaves of<i> Anisopus mannii</i> and the melanogenesis inhibitory activities

YE Feng; LYU Qinglin; ZHU Wanfang; FENG Feng; ZHANG Jie

doi:10.11665/j.issn.1000-5048.20180606

Journal of China Pharmaceutical University > 2018 > 49(6): 676-681. > DOI: 10.11665/j.issn.1000-5048.20180606

YE Feng, LYU Qinglin, ZHU Wanfang, FENG Feng, ZHANG Jie. Chemical constituents from the leaves of Anisopus mannii and the melanogenesis inhibitory activities[J]. Journal of China Pharmaceutical University, 2018, 49(6): 676-681. DOI: 10.11665/j.issn.1000-5048.20180606

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Chemical constituents from the leaves of Anisopus mannii and the melanogenesis inhibitory activities

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Abstract

The phytochemical studies on the leaves of Anisopus mannii led to the isolation of seven compounds by silica gel, ODS, DIAION HP-20, Sephadex LH-20 colunmn chromatographer, their structures were elucidated on the basis of the spectroscopic analyses(NMR, HRMS)and the comparisons with the literatures as 3β-acetoxylup-20(29)-ene( 1 ), 1-acetoxy-2-isopropyl-1-tridecene( 2 ), rutin( 3 ), 3, 6′-diferuloylsucrose( 4 ), 3-O-β-D-glucopyranosyl-3-β-hydroxyolean-12-en-28-oic acid 28-O-［α-L-rhamnopyra- nosyl-(1→2)-β-D-glucopyranosyl］ ester( 5 ), conduritol A( 6 ), hoyacarnoside I( 7 ). Meanwhile, the isolated compounds were evaluated for their inhibitory activities against melanogensis in B16 melanoma cells, as the results, all compounds exhibited melanogenesis-inhibitory activity and compound 5 showed a strongest activity(Melanin content: (27. 4±3. 5)%, Cell Viability: (54. 9±5. 6)% with a concentration of 30 μmol/L)which could be further developed.
- Anisopus mannii,
- chemical constituents,
- structural identification,
- melanogenesis-inhibitory activity

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