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ZHAO Dongmei, FANG Changjin, QIU Zhixia. Patent analysis for coagulation factor Xa inhibitors[J]. Journal of China Pharmaceutical University, 2019, 50(3): 364-373. DOI: 10.11665/j.issn.1000-5048.20190314
Citation: ZHAO Dongmei, FANG Changjin, QIU Zhixia. Patent analysis for coagulation factor Xa inhibitors[J]. Journal of China Pharmaceutical University, 2019, 50(3): 364-373. DOI: 10.11665/j.issn.1000-5048.20190314
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Patent analysis for coagulation factor Xa inhibitors

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    • Abstract
  • Anticoagulant drugs are widely used in the prevention and treatment of thromboembolic diseases. In recent years, coagulation factor Xa inhibitors have become a hot spot for the development of new anticoagulant drugs. However, the anticoagulant drugs currently used still have side-effects such as increased bleeding risk. This paper analyzes the patent applications of coagulation factor Xa inhibitors, and summarizes the development route of patent application of Bristol-Myers Squibb Company and Guangdong Dongyang Pharmaceutical Co. , Ltd. as representatives of key enterprises, in order to provide some useful references and recommendations for the development, patent protection countermeasure and intellectual property strategy of coagulation factor Xa for domestic pharmaceutical enterprises.
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    • References (7)
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    Xu C.CADD studies on FXa inhibitors and benzothiazole derivatives(计算机辅助药物设计对FXa抑制剂和苯并噻唑衍生物的研究)[D].Shanghai:Shanghai Institute of Technology,2016.
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    Chen H,Wang YG,Meng L,et al.Research progress on coagulation factor Xa inhibitors[J].Pharm Clin Res(药学与临床研究),2013,21(6):655-659.
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    Xu HR.Design,Synthesis and Biological activity studies of novel factor Xa inhibitors(新型凝血因子Xa抑制剂的设计、合成及生物活性研究)[D].Jinan:Shandong University,2017.
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