Advances in the research on mechanism of tumor metabolism regulated by c-Myc

LIU Yahui; GAO Lu; WANG Yajing; YAN Fang

doi:10.11665/j.issn.1000-5048.20210316

Journal of China Pharmaceutical University > 2021 > 52(3): 379-386. > DOI: 10.11665/j.issn.1000-5048.20210316

LIU Yahui, GAO Lu, WANG Yajing, YAN Fang. Advances in the research on mechanism of tumor metabolism regulated by c-Myc[J]. Journal of China Pharmaceutical University, 2021, 52(3): 379-386. DOI: 10.11665/j.issn.1000-5048.20210316

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Advances in the research on mechanism of tumor metabolism regulated by c-Myc

1.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009
2.
Department of Physiology, China Pharmaceutical University, Nanjing 210009, China

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Received Date: January 28, 2021
Revised Date: April 27, 2021

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Abstract

Abstract

The transcription factor c-Myc regulates the proliferation, differentiation, metabolism and other key processes of normal cells extensively.The unleashed MYC oncogene frequently produces abundant c-Myc protein, which directly regulates the gene expression of key metabolic enzymes, or tumor-related metabolic pathways by inhibiting microRNA, leading to abnormal metabolism characterized by heightened nutrients uptake, enhanced glycolysis and glutaminolysis, and elevated fatty acid and nucleotide synthesis.This paper briefly summarizes how c-Myc regulated metabolism on glycolysis, glutamine metabolism, tricarboxylic acid cycle, lipid metabolism and nucleotide synthesis in cancer cell,which provides some theoretical reference for the development of antitumor targets and drugs involving c-Myc.
- c-Myc,
- antitumor,
- glycolysis,
- glutamine metabolism,
- tricarboxylic acid cycle,
- lipid metabolism,
- nucleotide metabolism

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References (58)

References

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