Advances in the synthetic methods of bicyclo1.1.1pentane derivatives

HUANG Yu; ZHANG Yinsheng

doi:10.11665/j.issn.1000-5048.20220202

Journal of China Pharmaceutical University > 2022 > 53(2): 137-145. > DOI: 10.11665/j.issn.1000-5048.20220202

HUANG Yu, ZHANG Yinsheng. Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives[J]. Journal of China Pharmaceutical University, 2022, 53(2): 137-145. DOI: 10.11665/j.issn.1000-5048.20220202

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Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives

Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group, Nanjing 211100, China

Funds: This study was supported by the Program of Jiangsu Key Laboratory of Targeted Antiviral Research ([2019] No.1627)

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Received Date: October 31, 2021
Revised Date: December 21, 2021

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Abstract

Abstract

Bicyclo [1.1.1] pentane (BCP) is a kind of bridged ring skeleton with a three-dimensional structure. As a bioisostere of benzene ring, tert-butyl and alkyne, it has been widely used in the field of medicinal chemistry.With the expansion of its application, the synthesis of BCP and its derivatives has become an increasingly attractive research hotspot for scientists.Based on this, the present article summarizes the main synthetic strategies and methods of BCP derivatives, in the hope of providing some reference for drug discovery researchers and some insight for new synthetic methods of such compounds.
- bcyclo [1.1.1] pentane (BCP),
- synthetic methods,
- advances

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References (35)

References

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