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WEI Naijie, WANG Guangji, ZHANG Jingwei. Advances in research on visualization of living cell drugs in vivo[J]. Journal of China Pharmaceutical University, 2022, 53(2): 156-163. DOI: 10.11665/j.issn.1000-5048.20220204
Citation: WEI Naijie, WANG Guangji, ZHANG Jingwei. Advances in research on visualization of living cell drugs in vivo[J]. Journal of China Pharmaceutical University, 2022, 53(2): 156-163. DOI: 10.11665/j.issn.1000-5048.20220204
shu

Advances in research on visualization of living cell drugs in vivo

  • Key Labratory Jiangsu Provincial of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No.82173887, 82073928)
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  • Received Date: December 02, 2021
  • Revised Date: March 08, 2022
    Graphical Abstract
    • Abstract
  • The development of living cell drugs and their successful application in clinical treatments require full clarification of the fate of cells after transplantation, which is critical to the safety and efficacy of living cell drugs.In order to solve this problem, cell imaging technology has come into our sight, and the use of visualization technology for non-invasive tracing of living cell drugs could reveal the distribution, homing and activity of living cell drugs in the body, which helps to determine the best number of transplanted cells, optimize the administration scheme, improve the transplantation efficiency, enhance the targeting of transplanted cells, and reduce the potential off-target accumulation risk.This paper summarizes the research advances of non-invasive visual tracing in vivo for living cell drugs from the perspectives of radionuclide imaging, magnetic resonance imaging, magnetic particle imaging, computed tomography imaging, fluorescence imaging and multimodal imaging.The aim is to obtain the biological behavior of living cell drugs in vivo with the application of appropriate contrast agent and tracing technology, and provide a more reasonable scientific basis for the research and development of living cell drugs and their transplantation therapy.
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