Effect of chemical modification on biological properties of hyaluronic acid

JIA Yue; ZHANG Hengchuan; ZHAO Yuanyuan; YIN Shaoping; YIN Tingjie

doi:10.11665/j.issn.1000-5048.2024042103

Journal of China Pharmaceutical University > 2025 > 56(1): 119-124. > DOI: 10.11665/j.issn.1000-5048.2024042103

JIA Yue, ZHANG Hengchuan, ZHAO Yuanyuan, et al. Effect of chemical modification on biological properties of hyaluronic acid[J]. J China Pharm Univ, 2025, 56(1): 119 − 124. DOI: 10.11665/j.issn.1000-5048.2024042103

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Effect of chemical modification on biological properties of hyaluronic acid

1.
School of Pharmacy, China Pharmaceutical University, Nanjing 210009
2.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023
3.
Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050200, China

Funds: This study was supported by the National Natural Science Foundation of China（No. 81972835，No.82003305）

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Received Date: April 20, 2024

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Abstract

Abstract

Hyaluronic acid (HA) possesses excellent biocompatibility, biodegradability, and non-immunogenicity, and exhibits active targeting capability to receptors such as cluster of differentiation 44 (CD44). Therefore, HA has become an important material for the design and preparation of drug delivery carriers in recent years. HA is rich in functional groups that can be chemically modified, but different modification methods and sites can affect its biological properties. This paper summarizes and discusses the effects of chemical modification on the biological properties of HA based on the formation mechanisms of such properties, as well as the derivatization and characterization methods of HA, so as to provide some reference for rational research on chemical modification of HA.
- hyaluronic acid,
- chemical modification,
- biological properties

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References (41)

References

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Effect of chemical modification on biological properties of hyaluronic acid