AIM The purpose is to develop of the general route for the synthesis of lomerizine dihydrochloride. METHODS Pyrogallic acid was converted to 1,2,3 trimethoxybenzene and followed by Blanc reaction with paraformaldehyde to afford 2,3,4 trimethoxybenzyl
GUO Di-liang, LIU Guan-nan, LI Jian, ZHOU Yu, XU Jin-yi, JIANG Hua-liang, LIU Hong. Improved synthesis of raltegravir[J]. Journal of China Pharmaceutical University, 2009, 40(4): 297-301.