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NIU Ben, SHAN Jia-qi, WU Xiao-ming, SUN Hong-bin. Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol[J]. Journal of China Pharmaceutical University, 2009, 40(3): 205-208.
Citation: NIU Ben, SHAN Jia-qi, WU Xiao-ming, SUN Hong-bin. Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol[J]. Journal of China Pharmaceutical University, 2009, 40(3): 205-208.

Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol

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  • Aim :To improve the synthesis for 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol. Methods :Dehydration of D-mannitol,followed by a reaction sequence of selective protection,benzylation,deprotection,tritylation,benzylation and removal of the trityl group,afforded the title compound. Results :Based on the improvement of the reported synthetic route,2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8.3%. Conclusion :This new method features mild reaction conditions and facile work-up.
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