• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
CHENG Yu-si, DAI De-zai, JI Hui, DAI Yin. Mechanism of endothelin receptor antagonist CPU0213 and calcium antagonist CPU86017 ameliorated rats′ heart failure induced by isoproterenol[J]. Journal of China Pharmaceutical University, 2011, 42(1): 58-63.
Citation: CHENG Yu-si, DAI De-zai, JI Hui, DAI Yin. Mechanism of endothelin receptor antagonist CPU0213 and calcium antagonist CPU86017 ameliorated rats′ heart failure induced by isoproterenol[J]. Journal of China Pharmaceutical University, 2011, 42(1): 58-63.
shu

Mechanism of endothelin receptor antagonist CPU0213 and calcium antagonist CPU86017 ameliorated rats′ heart failure induced by isoproterenol

More Information
    Graphical Abstract
    • Abstract
  • The purpose of this experiment was to verify whether endothelin receptor antagonist CPU0213 and calcium antagonist CPU86017 improved isoproterenol (ISO)-induced heart failure in rats by inhibiting p66Shc and PKCε .40 SD male rats were randomly divided into 5 groups.Except for the normal group,the other groups were given isoproterenol for 10 d (1mg/kg,sc).Three treatment groups (sc,mg/kg,from day 10-11) included: aminoguanidine group 30 and CPU0213 group 30 and CPU86017 group 4.It was found that mRNA or the protein expressions of endothelin receptor A (ETA),iNOS,p66Shc,PKCε,OBRb,NADPH oxidase p67 phox and leptin increased in ISO group.After drug treatment ,the above abnormal indicators were mitigated and even reversed.Hence,it suggested that CPU0213 and CPU86017 improved the ISO- induced heart failure by inhibiting the endothelin receptor and oxidative stress and down-regulating the expressions of p66Shc and PKCε.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]YU Zexuan, JU Caoyun, ZHANG Can. Construction and application of gene delivery systems for primary dendritic cells[J]. Journal of China Pharmaceutical University, 2021, 52(4): 438-446. DOI: 10.11665/j.issn.1000-5048.20210406
    [2]WANG Xiaojian, FU Jihua, TANG Yiqun, YIN Dali, YOU Qidong. Synthesis,biological evaluation and molecule docking of novel desloratadine derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(1): 39-43. DOI: 10.11665/j.issn.1000-5048.20130106
    [3]TAN Ya-yu, CHEN Ya-dong, YOU Qi-dong, LI Man-hua. Diverse drug-hERG potassium channel interactions[J]. Journal of China Pharmaceutical University, 2011, 42(5): 473-480.
    [4]YAO Jing, FAN Ying, ZHOU Jian-ping, LI Fei-yan. Advances on the study of new cationic polymers as gene vectors[J]. Journal of China Pharmaceutical University, 2011, 42(2): 176-181.
    [5]Construction of a high epidaunorubicin-producing strain by gene recombination[J]. Journal of China Pharmaceutical University, 2010, 41(3): 283-288.
    [7]Identification of a Novel HERG Gene Mutation by PCR SSCP and Cloning Analyses[J]. Journal of China Pharmaceutical University, 1999, (1): 68-70.
    [8]Effect of Age on the Gene Transcription of Phosphoenolpyruvate Carboxykinase[J]. Journal of China Pharmaceutical University, 1995, (1): 52+47-52.
    [9]High Expression of Hepatitis B Core Gene in E. coli[J]. Journal of China Pharmaceutical University, 1993, (1): 60-62.
    [10]High Expression of Hepatitis B e Gene in E. coli[J]. Journal of China Pharmaceutical University, 1992, (5): 290-293.

Catalog

    Get Citation
    PDF
    XML
    Article views (1526) PDF downloads (2383) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：293011

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return