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ZHANG Guo-lin, XU Ming, DAI De-zai, XI Tao, DAI Yin. Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213[J]. Journal of China Pharmaceutical University, 2011, 42(5): 452-457.
Citation: ZHANG Guo-lin, XU Ming, DAI De-zai, XI Tao, DAI Yin. Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213[J]. Journal of China Pharmaceutical University, 2011, 42(5): 452-457.
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Endothelin-NADPH oxidase mediates cardiomyocytes dysfunction caused by H2O2 and interventions by CPU0213

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  • Over-activated NADPH oxidase and endothelin（ET）system are the main mechanism of cardiomyocytes dysfunction.This research mainly focuses on the hypothesis that CPU0213 attenuates cardiomyocytes dysfunction by inhibiting the over-expression of ET-NADPH oxidase.Cardiomyocytes were divided into groups:control, H2O2 group, H89/Bis, APO/DPI, CPU0213 group.The expression of FKBP12.6, SERCA2a and CASQ2 were down-regulated and pPKCε/PKCε，NADPH oxidase and ETAR/ETBR were up-regulated in H2O2 treated group,which implyed the involvement of PKCε.Endothelin receptor antagonist CPU0213 attenuated the abnormal expression of FKBP12.6, SERCA2a and CASQ2 by inhibiting pPKC-NADPH pathway.
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