• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
YE Qing, HUO Mei-rong, ZHOU Jian-ping. Pharmacokinetics and in situ absorption in rat intestine of paclitaxel-loaded amphiphilic chitosan micelle[J]. Journal of China Pharmaceutical University, 2012, 43(5): 401-405.
Citation: YE Qing, HUO Mei-rong, ZHOU Jian-ping. Pharmacokinetics and in situ absorption in rat intestine of paclitaxel-loaded amphiphilic chitosan micelle[J]. Journal of China Pharmaceutical University, 2012, 43(5): 401-405.
shu

Pharmacokinetics and in situ absorption in rat intestine of paclitaxel-loaded amphiphilic chitosan micelle

More Information
    Graphical Abstract
    • Abstract
  • The aim of this study was to investigate the potential feasibility of the N-octyl-O,N-carboxymethyl chitosan (OCC) micelles as oral administration carriers for paclitaxel (PTX) by pharmacokinetics and in situ absorption in rat intestine using Taxol as control.After oral administration of PTX-OCC micelles,the area under the plasma concentration-time curve (AUC) and the maximum concentration (cmax) were significantly larger than those of Taxol (P<0.05).Relative bioavailability for PTX-OCC micelles was 331.4% of that of Taxol.The absorption of PTX-OCC at different segments of intestine was significantly higher than those of Taxol(P<0.05).The apparent absorption rate (Ka)and the effective permeation coefficient (Peff) at the duodenum were a little higher than those of jejunum,ileum and colon (P>0.05).In conclusion，OCC might be a promising carrier for oral administration of poorly water-soluble drugs.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]SHANG Feiyang, LIU Chengbo, TAN Hongzhou, HE Bing, HE Liqin. Design, synthesis and antiplatelet aggregation activity of 3-acetyl-7-hydroxycoumarin derivatives[J]. Journal of China Pharmaceutical University, 2024, 55(3): 367-374. DOI: 10.11665/j.issn.1000-5048.2023072901
    [2]DAI Weiguo, TAN Hongzhou, GU Hongxia, HE Bing, HE Liqin, HUANG Peng. Design, synthesis and anti-platelet aggregation activity of paeonol oxime derivatives[J]. Journal of China Pharmaceutical University, 2022, 53(5): 535-541. DOI: 10.11665/j.issn.1000-5048.20220504
    [3]GAO Yang, YIN Wei, LIU Jingchao, KANG Fenghua, JIAN Yanlin, ZHOU Jinpei, HUANG Zhangjian, ZHANG Yihua. Design, synthesis and antiplatelet evaluation of tetramethylpyrazine/chalcone hybrids[J]. Journal of China Pharmaceutical University, 2017, 48(1): 23-30. DOI: 10.11665/j.issn.1000-5048.20170104
    [4]WANG Xiaoli, WANG Zhaoya, WANG Linna, JI Hui, ZHANG Yihua, YIN Jian. Design, synthesis and evaluation of hydrogen sulfide-releasing derivatives of ring opening 3-n-butylphthalide as novel platelet aggregation inhibitors[J]. Journal of China Pharmaceutical University, 2016, 47(2): 158-162. DOI: 10.11665/j.issn.1000-5048.20160205
    [5]FANG Jiangen, WANG Xuliang, LING Jingjing, YIN Wei, XU Jinyi, JI Hui, ZHANG Yihua. Synthesis and antiplatelet aggregation/antioxidant activity of 3-alkyl-benzo［c］ selenophen-1(3H)-ones[J]. Journal of China Pharmaceutical University, 2015, 46(5): 552-555. DOI: 10.11665/j.issn.1000-5048.20150506
    [6]YANG Chunyu, HUANG Zhangjian, LING Jingjing, JI Hui, LAI Yisheng, XU Jinyi, PENG Sixun, ZHANG Yihua. Synthesis and evaluation of carbamate-isosorbide-3-n-butylphthalide ring opening derivative trihybrids as novel platelet aggregation inhibitors[J]. Journal of China Pharmaceutical University, 2013, 44(3): 202-206. DOI: 10.11665/j.issn.1000-5048.20130302
    [7]ZHANG Bo-yu, SHAN Jia-qi, LIU Lin, JIAO Bo, SUN Hong-bin. Synthesis and antiplatelet aggregation activities of prasugrel derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(4): 305-309.
    [8]Synthesis and anti-platelet aggregation activity of substituted (E)-1，2-diarylethene compounds[J]. Journal of China Pharmaceutical University, 2010, 41(5): 419-423.
    [9]LI Bao-quan, LI Nian-guang, FENG Feng, TANG Yu-ping, DUAN Jin-ao. Synthesis and anti-platelet aggregation activities of ferulic acid esters[J]. Journal of China Pharmaceutical University, 2009, 40(6): 486-490.
    [10]Synthesis and Antiplatelet Aggregation of N Acylated Tetrahydrobenzylisoquinoline[J]. Journal of China Pharmaceutical University, 1997, (5): 3+6-7.

Catalog

    Get Citation
    PDF
    XML
    Article views (1427) PDF downloads (2593) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：432110

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return