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XIAN Wenying, XU Lujie, ZHANG Guangqin. Effects of H2S on tetrodotoxin-sensitive sodium currents in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2014, 45(1): 97-101. DOI: 10.11665/j.issn.1000-5048.20140118
Citation: XIAN Wenying, XU Lujie, ZHANG Guangqin. Effects of H2S on tetrodotoxin-sensitive sodium currents in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2014, 45(1): 97-101. DOI: 10.11665/j.issn.1000-5048.20140118
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Effects of H2S on tetrodotoxin-sensitive sodium currents in mouse dorsal root ganglion neurons

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  • The effects of hydrogen sulfide(H2S)on tetrodotoxin-sensitive(TTX-S)sodium currents in mouse dorsal root ganglion(DRG)neurons, were studied by use of the whole-cell patch clamp technique. NaHS(a donor of H2S)increased TTX-S sodium currents in a concentration-dependent manner; the EC50 was 119 μmol/L and Hill coefficient was 1. 105. NaHS 100 μmol/L markedly shifted the steady state activation and inactivation curves of TTX-S sodium currents towards more positive potential to 9. 8 and 10. 4 mV, respectively, yet with no significant difference on recovery from inactivation of TTX-S sodium channels. Therefore, H2S increased the TTX-S sodium currents and altered the activation and the inactivation kinetics of TTX-S sodium channel, which may contribute to one of its mechanisms in pain.
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    • References (14)
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