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HUANG Yun, KANG Ziyao, ZHANG Guangqin. Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2016, 47(5): 609-613. DOI: 10.11665/j.issn.1000-5048.20160518
Citation: HUANG Yun, KANG Ziyao, ZHANG Guangqin. Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2016, 47(5): 609-613. DOI: 10.11665/j.issn.1000-5048.20160518
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Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons

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  • To elucidate possible mechanisms and targets of honokiol(Hnk)for hte treatment of pain, the effects of Hnk on tetrodoxin-senstive(TTX-S)sodium current(INa)were studied in acutely dissociated mouse dorsal root ganglion(DRG)neurons with whole-cell patch clamp technique. Hnk inhibited TTX-S INa currents in a concentration-dependent manner. At 30 μmol/L, Hnk obviously shifted the steady state activation of TTX-S INa toward more positive potentials by 10. 2 mV and prolonged the time course of recovery of sodium current, yet with no significant difference on recovery from inactivation of TTX-S sodium channel.
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  • [1]
    Woodbury A,Yu SP,Chen D,et al.Honokiol for the treatment of neonatal pain and prevention of consequent neurobehavioral disorders[J].J Nat Prod,2015,78(11):2531-2536.
    [2]
    Amorati R,Zotova J,Baschieri A,et al.Antioxidant activity of magnolol and honokiol:kinetic and mechanistic investigations of their reaction with peroxyl radicals[J].J Org Chem,2015,80(21):10651-10659.
    [3]
    Fang CY, Chen SJ, Wu HN, et al. Honokiol,a lignan biphenol derived from the magnolia tree,inhibits dengue virus type 2 infection[J].Viruses,2015,7(9):4894-4910.
    [4]
    Blackman P.Shin pain in athletes-assessment and management[J].Aust Fam Physician,2010,39(1/2):24-29.
    [5]
    Cerutis DR,Weston MD,Ogunleye AO,et al.Lysophosphatidic acid(LPA)18:1 transcriptional regulation of primary human gingival fibroblasts[J].Genom Data,2014,2:375-377.
    [6]
    da Silva KA,Paszcuk AF,Passos GF,et al.Activation of cannabinoid receptors by the pentacyclic triterpene alpha,beta-amyrin inhibits inflammatory and neuropathic persistent pain in mice[J].Pain,2011,152(8):1872-1887.
    [7]
    Hou B,Chen H,Qu X,et al.Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes[J].Neuroreport,2015,26(16):981-987.
    [8]
    Nakamura M,Jang IS.pH-dependent inhibition of tetrodotoxin-resistant Na+ channels by diclofenac in rat nociceptive neurons[J].Prog Neuropsychopharmacol Biol Psychiatry,2016,64:35-43.
    [9]
    Zhu H,Yu Y,Zheng L,et al.Chronic inflammatory pain upregulates expression of P2Y2 receptor in small-diameter sensory neurons[J].Metab Brain Dis,2015,30(6):1349-1358.
    [10]
    Ho C,O′leary ME.Single-cell analysis of sodium channel expression in dorsal root ganglion neurons[J].Mol Cell Neurosci,2011,46(1):159-166.
    [11]
    Chahine M,O′Leary ME.Regulation/modulation of sensory neuron sodium channels[J].Handb Exp Pharmacol,2014,221:111-135.
    [12]
    Takahashi I, Yoshion M. Functional coupling between sodium-activated potassium channels and voltage-dependent persistent sodium currents in cricket Kenyon cells[J].J Neurophysiol,2015,114(4):2450-2459.
    [13]
    Kao DJ,Li AH,Chen JC,et al.CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons[J].J Neuroinflammation,2012,9:189.
    [14]
    Przewocki R,Przewocka B.Opioids in chronic pain[J].Eur J Pharmacol,2001,429(1):79-91.
    [15]
    Hon HK,Lee BH,Park MH,et al.Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration[J].Eur J Pharmacol,2013,702(1/2/3):165-173.
    [16]
    Zou Z, Lu Y, Dong M, et al. Effect of homocysteine on voltage-gated sodium channel currents in primary cultured rat caudate nucleus neurons and its modulation by 2-arachidonylglycerol[J].J Mol Neurosci,2015,57(4):477-485.
    [17]
    Christidis N,Kang I,Cairns BE,et al.Expression of 5-HT3 receptors and TTX resistant sodium channels(Na(V)1.8)on muscle nerve fibers in pain-free humans and patients with chronic myofascial temporomandibular disorders[J].J Headache Pain,2014,15:63.
    [18]
    Lin YR,Chen HH,Lin YC,et al.Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain[J].J Biomed Sci,2009,16:94.
    [19]
    Ghelardini C, Desaphy JF, Muraglia M, et al. Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models[J].Neuroscience,2010,169(2):863-873.
    [20]
    Scanio MJ,Shi L,Drizin I,et al.Discovery and biological evaluation of potent,selective,orally bioavailable,pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain[J].Bioorg Med Chem,2010,18(22):7816-7825.
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