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LYU Guangyun, WANG Shuangshuang, HANG Taijun, SONG Min. Qualitative and quantitative analysis of components of Radix Polygalae in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii[J]. Journal of China Pharmaceutical University, 2016, 47(3): 329-336. DOI: 10.11665/j.issn.1000-5048.20160314
Citation: LYU Guangyun, WANG Shuangshuang, HANG Taijun, SONG Min. Qualitative and quantitative analysis of components of Radix Polygalae in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii[J]. Journal of China Pharmaceutical University, 2016, 47(3): 329-336. DOI: 10.11665/j.issn.1000-5048.20160314
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Qualitative and quantitative analysis of components of Radix Polygalae in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii

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    • Abstract
  • The purpose of this research was to explore the differences of the components of Radix Polygalae in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii. An HPLC-Q-TOF-MS/MS method and an HPLC-UV method were established for the identification and determination of the components of Radix Polygalae, respectively. HPLC separation was carried out on a C18 column(250 mm×4. 6 mm, 5 μm)with linear gradient elution using a mobile phase consisting of acetonitrile and 0. 1% formic acid aqueous solution. Mass spectrometry with ESI source was performed in the positive ion mode to scan MS data including total ion chromatograms and ion peaks of Radix Polygalae. Eight components including 3, 4, 5-trimethoxycinnamic acid, p-methoxycinnamic acid, tenuifolin, sibiricose A5, polygalaxanthone III, tenuifoliside B, 3, 6′-disinapoly sucrose, and tenuifoliside A were identified according to the reference substance retention time, MS data and literatures. There was no significant variation found in the contents of eight chemical constituents of Radix Polygalae. The qualification and quantitation study of the components in herbal pair of Radix Polygalae and Rhizoma Acori Tatarinowii provide the methodological basis for compatibility mechanism exploration in vivo.
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    • References (14)
  • [1]
    Lyu JS.Study of SHI Jin-mo′s Pair Drugs(施今墨对药)[M].3rd ed.Beijing:People′s Military Medical Press,2007:265-266.
    [2]
    Lyu HM,Zhu C,Liao YJ,et al.Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways[J].Resp Physiol Neurobi,2015,216:43-51.
    [3]
    Tian F, Jiang Y, Zhang K, et al. The effect and mechanism of Polygala tenuifolia glycoside on SAM-P/8[J].Geriatr Health Care(老年医学与保健),2004,10(3):137-139.
    [4]
    Chen Q,Cao YG,Zhang CH.Effect of tenuigenin on cholinergic decline induced by β-amyloid peptide and ibotenic acid in rats[J].Acta Pharm Sin(药学学报),2002,37(12):913-917.
    [5]
    Nikaido T,Ohmoto T,Saitoh H,et al.Inhibitors of cyclic adenosine monophosphate phosphodiesterase in Polygala tenuifolia[J].Chem Pharm Bull,1982,30(30):2020-2024.
    [6]
    Chinese Pharmacopoeia Commission.Chinese Pharmacopoeia:part 1(中华人民共和国药典:一部)[S].Beijing:China Medical Science Press,2015:156-157.
    [7]
    Li J,Dong XB,Jiang Y,et al.HPLC determination of total saponins in Radix Polygalae[J].Chin J Pharm Anal(药物分析杂志),2007,27(9):1329-1332.
    [8]
    Yang XD,Xu LZ,Yang SL.Advances in the research of chemistry and pharmacology of xanthones extracted from Polygala L.[J].Nat Prod Res Dev(天然产物研究与开发),2000,12(5):88-94.
    [9]
    Liu P,Wang DX,Guo DH,et al.Antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd.in pharmacological depression model[J].Chin Pharm J(中国药学杂志),2008,43(18):1391-1394.
    [10]
    Tu HH,Liu P,Mu L,et al.Study on antidepressant components of sucrose ester from Polygala tenuifolia[J].Chin J Chin Mater Med(中国中药杂志),2008,33(11):1278-1280.
    [11]
    Zhang WJ,Zheng XH,Fang MF,et al.Analysis of diversify in matched pair of Polygala tenuifolia Willd.and Acorus Tatarinowii Schott by HPLC[J].China Pharm(中国药业),2009,18(15):6-7.
    [12]
    Wang J, Liu XM, Chang Q, et al. Chemical constituents from alkaline hydrolysis products of total saponins in Radix Palygalae[J].Cent South Pharm(中南药学),2010,8(11):811-814.
    [13]
    Ikeya Y,Sugama K,Okada M,et al.Four new phenolic glycosides from Polygala tenuifolia[J].Chem Pharm Bull,1991,39(10):2600-2605.
    [14]
    Jiang Y,Tu PF.Studies on the chemical constituents in root bark of Polygala tenuifolia(Ⅱ)[J].China J Chin Mater Med(中国中药杂志),2004,29(8):751-753.
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