• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
SUN Biao, AO Yunlin, WANG Dezhi, WANG Junya, YE Wencai, ZHANG Xiaoqi. Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens[J]. Journal of China Pharmaceutical University, 2022, 53(2): 178-184. DOI: 10.11665/j.issn.1000-5048.20220207
Citation: SUN Biao, AO Yunlin, WANG Dezhi, WANG Junya, YE Wencai, ZHANG Xiaoqi. Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens[J]. Journal of China Pharmaceutical University, 2022, 53(2): 178-184. DOI: 10.11665/j.issn.1000-5048.20220207
shu

Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens

  • 1.

    Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632

  • 2.

    Guangdong Engineering Research Center for Modernization of TCM, Ji' nan University, Guangzhou 510632

  • 3.

    NMPA Key Laboratory for Quality Evaluation of TCM, Guangzhou 510632, China

Funds: This study was supported by the National Natural Science Foundation of China (No.U1801287, No.82073712), the Science and Technology Planning Project of Guangdong Province (No.2020B1111110004) and the Science and Technology Planning Project of Guangzhou (No.20212210005)
More Information
  • Received Date: August 26, 2021
  • Revised Date: February 28, 2022
    Graphical Abstract
    • Abstract
  • To study the chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens (family of Moraceae), fifteen compounds were isolated from the stems and leaves of H.scandens by silica gel, Sephadex LH-20, ODS, and preparative HPLC chromatography.The structures were identified by physicochemical data and spectroscopic method as tectochrysin (1), chrysin (2), 5-hydroxy-3, 4'', 6, 7-tetramethoxyflavone (3), (2S)-5-hydroxy-7, 8-dimethoxyflavanone (4), imperatorin (5), phellopterin (6), ethyl 4-hydroxy-3-(3''-methyl-2''-butenyl)benzoate (7), p-hydroxy-phenylpropionic acid (8), ethyl p-hydroxycinnamate (9), p-hydroxybenzaldehyde (10), anofinic acid (11), 5,6-dehydrokavain (12), physcion (13), olean-12-ene-3,?11-dione (14) and ergosta-4, 6, 8 (14), 22-tetraen-3-one (15), respectively.All compounds were isolated from this plant for the first time.
    • FullText(HTML)
    • References (24)
  • [1]
    . Chin Tradit Patent Med（中成药），2012，34（6）：1119-1122.
    [2]
    Xu BL，Jiang JQ. Study on chemical constituents of ethyl acetate fraction of Humulus scandens［J］. Pharm Clin Res（药学与临床研究），2014，22（2）：124-127.
    [3]
    Cao L. Chemical constituents from Humulus scandens［J］. Chin J Ethnomed Ethnopharm（中国民族民间医药），2012，21（11）：24-25.
    [4]
    Ma FG，Zhang YP. Advances in pharmacological effects and chemical constituents of traditional Chinese medicine Humulus officinalis［J］. World Latest Med Inf（世界最新医学信息文摘），2017，17（14）：46-48，52.
    [5]
    Wang X，Qin MJ，Wu G，et al. Chemical constituents of the leaves of Iris songarica［J］. J China Pharm Univ（中国药科大学学报），2006，37（3）：222-225.
    [6]
    Shang XY，Li S，Wang SJ，et al. Flavonoids from Bauhinia aurea［J］. Chin Tradit Herbal Drugs（中草药），2009，40（2）：196-199.
    [7]
    Xia SL，Cao Y，Li QL，et al. Chemical constituents of Artemisia rupestris［J］. Chin Tradit Herbal Drugs（中草药），2020，51（13）：3393-3398.
    [8]
    Kuroyanagi M，Sato M，Ueno A，et al. Flavonoids from Andrographis paniculata［J］. Chem Pharm Bull，1987，35（11）：4429-4435.
    [9]
    Thanh PN，Jin WY，Song G，et al. Cytotoxic coumarins from the root of Angelica dahurica［J］. Arch Pharm Res，2004，27（12）：1211-1215.
    [10]
    Fu Y，Bai Y，DaWa ZM，et al. Chemical constituents of Incarvillea younghusbandii［J］. Chin J Chin Mater Med（中国中药杂志），2010，35（1）：58-62.
    [11]
    Pereda-Miranda R，Bernard CB，Durst T，et al. Methyl 4-hydroxy-3-（3''-methyl-2''-butenyl）benzoate，major insecticidal principle from Piper guanacastensis［J］. J Nat Prod，1997，60（3）：282-284.
    [12]
    Guan HJ，Zhang X，Tu FJ，et al. Chemical constituents of Dendrobium candidum［J］. Chin Tradit Herbal Drugs（中草药），2009，40（12）：1873-1876.
    [13]
    Zhu H，Zhang Z，Huang WZ，et al. A new diphenylpropanoid from Cassia floribunda［J］. Chin Tradit Herbal Drugs（中草药），2020，51（11）：2871-2877.
    [14]
    Li YL，Dai J，Huang WH，et al. Chemical constituents and antiviral activity of Polygala fallax［J］. Chin Tradit Herbal Drugs（中草药），2009，40（3）：345-348.
    [15]
    Ando H，Hirai Y，Fujii M，et al. The chemical constituents of fresh Gentian Root［J］. J Nat Med，2007，61（3）：269-279.
    [16]
    Roman Junior WA，Gomes DB，Zanchet B，et al. Antiproliferative effects of pinostrobin and 5，6-dehydrokavain isolated from leaves of Alpinia zerumbet［J］. Rev Bras Farmacogn，2017，27（5）：592-598.
    [17]
    ShaoL，SunB，WangXW，et al. Chemical constituents of twigs and leaves of Sindechites henryi［J］. J Jinan Univ Nat Sci Med Ed ［暨南大学学报（自然科学与医学版）］，2021，42（1）：26-32.
    [18]
    Qi SH，Wu DG，Ma YB，et al. Chemical constituents of Ailanthus triphysa［J］. Chin Tradit Herbal Drugs（中草药），2003，34（7）：590-592.
    [19]
    Fujimoto H，Nakamura E，Okuyama E，et al. Six immunosuppressive features from an ascomycete，Zopfiella longicaudata，found in a screening study monitored by immunomodulatory activity［J］. Chem Pharm Bull（Tokyo），2004，52（8）：1005-1008.
    [20]
    WMNHWSalleh，Nafiah MA，Yen KH，et al. Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz［J］. Bull Chem Soc Eth，2021，34（3）：625-632.
    [21]
    Imran M，Irfan A，Ibrahim M，et al. Carbonic anhydrase and cholinesterase inhibitory activities of isolated flavonoids from Oxalis corniculata L. and their first-principles investigations［J］. Ind Crops Prod，2020，148（1）：112285.
    [22]
    Takomthong P，Waiwut P，Yenjai C，et al. Structure-activity analysis and molecular docking studies of coumarins from Toddalia asiatica as multifunctional agents for Alzheimer''s disease［J］. Biomedicines，2020，8（5）：107.
    [23]
    Huang Y，Liao XP，Wang HW，et al. Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats［J］. Sci Rep，2021，11（1）：8590.
    [24]
    Li LJ，Cai YC，Sun X，et al. Tyrosinase inhibition by p-coumaric acid ethyl ester identified from camellia pollen［J］. Food Sci Nutr，2020，9（1）：389-400.
    • Related Articles

  • Related Articles

    [1]LOU Fangning, ZHENG Mingyue, CHEN Kaixian, ZHANG Sulin. Research progress of cGAS-STING signaling pathway modulators in immunotherapy[J]. Journal of China Pharmaceutical University, 2024, 55(1): 15-25. DOI: 10.11665/j.issn.1000-5048.2023112402
    [2]CHEN Yu, XU Zhimeng, LI Ping. Calcium signal-mediated activation of NLRP3 inflammasome[J]. Journal of China Pharmaceutical University, 2021, 52(5): 513-521. DOI: 10.11665/j.issn.1000-5048.20210501
    [3]LIU Yuhong, ZHANG Fangfang, LIU Jianxing, LIU Yue, YANG Yue, JIN Liang. Interplay between non-coding RNA and insulin signaling pathway and its clinical application[J]. Journal of China Pharmaceutical University, 2021, 52(3): 279-286. DOI: 10.11665/j.issn.1000-5048.20210303
    [4]LIN Aihua, LIU Jin, CHEN Yanqing, ZHANG Yan, YU Yang. Effect of serum amyloid A on microglial migration and its mechanism[J]. Journal of China Pharmaceutical University, 2020, 51(5): 591-598. DOI: 10.11665/j.issn.1000-5048.20200511
    [5]LIU Li, ZHANG Qianwen, NONG Cheng, ZHANG Xi, XU Xiaoting, Mohammed Ismail, XIAO Li, JIANG Zhenzhou, ZHANG Luyong, SUN Lixin. Research progress of lncRNA regulating signal transduction pathway in liver diseases[J]. Journal of China Pharmaceutical University, 2020, 51(3): 277-286. DOI: 10.11665/j.issn.1000-5048.20200304
    [6]TAN Chengning, HUANG Jinghan, LI Chunhong, XIA Zhining, YANG Fengqing. Applications of proteomics in the study of cell signal pathways[J]. Journal of China Pharmaceutical University, 2017, 48(4): 384-395. DOI: 10.11665/j.issn.1000-5048.20170402
    [7]MEI Huifang, SUN Lixin, JIANG Zhenzhou, ZHANG Luyong. Sphingosine 1-phosphate signaling pathway:a novel target for regulation of epithelial and endothelial barrier function[J]. Journal of China Pharmaceutical University, 2016, 47(6): 654-660. DOI: 10.11665/j.issn.1000-5048.20160604
    [8]ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319
    [9]PAN Ling-zhen, YAN Zhi-yong, ZUO Chang-ying, CHEN Chong, LI Shao-hua. Influence of long-term usage of diazepam on neuroactive ligand-receptor interaction signaling pathway[J]. Journal of China Pharmaceutical University, 2011, 42(5): 443-446.
    [10]ON-LINE ANALYSIS OF BIOMEDICAL SIGNAL WITH A MICROCOMPUTER SYSTEM[J]. Journal of China Pharmaceutical University, 1987, (3): 199-202.

  • Cited by

    Periodical cited type(8)

    1. 王忠利. 糖尿病并发症的药物防治研究进展. 中国城乡企业卫生. 2023(06): 39-41 .
    2. 卢薇，林丹，王挺挺，陈旭，周鹏. 柴芍六君子汤加减治疗2型糖尿病的临床疗效观察. 中药材. 2023(04): 1026-1029 .
    3. 李链，上官钰，戴勇. 蛋白组学在肾脏疾病中的应用. 国际泌尿系统杂志. 2022(04): 767-770 .
    4. 李链，上官钰，戴勇. 蛋白组学在肾脏疾病中的应用. 国际泌尿系统杂志. 2022(04): 767-770 .
    5. 郭笑丹，席小雯，田林涛，徐杰. 利拉鲁肽 德谷胰岛素联合二甲双胍在难治性2型糖尿病治疗中的应用效果观察. 山西医药杂志. 2022(15): 1760-1763 .
    6. 操映倩，周立分，余宏，薛亚楠，艾志福，罗小泉，章常华. 基于转录组学和蛋白质组学分析小檗碱抗糖尿病慢性炎症机制. 中国新药杂志. 2021(05): 424-433 .
    7. 陈凡，葛莉，黄萍萍，江心泳，赖玉婷，庞书勤. 系统评价胎盘差异表达蛋白对妊娠糖尿病大鼠模型胎盘生长发育的影响. 中国实验动物学报. 2021(03): 343-353 .
    8. 王银虹. 早期营养干预对糖尿病足患者肾功能的影响. 航空航天医学杂志. 2021(07): 783-785 .

    Other cited types(4)

Catalog

    Get Citation
    PDF
    XML
    Article views (310) PDF downloads (314) Cited by(12)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：297250

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return