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OU Meng, YAN Yinyu, MA Yu, HONG Jin, DING Ya. Nucleic acid drug delivery strategies without the lysosomal pathway[J]. Journal of China Pharmaceutical University, 2023, 54(1): 34-48. DOI: 10.11665/j.issn.1000-5048.20221115001
Citation: OU Meng, YAN Yinyu, MA Yu, HONG Jin, DING Ya. Nucleic acid drug delivery strategies without the lysosomal pathway[J]. Journal of China Pharmaceutical University, 2023, 54(1): 34-48. DOI: 10.11665/j.issn.1000-5048.20221115001
shu

Nucleic acid drug delivery strategies without the lysosomal pathway

  • 1.

    Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198

  • 2.

    Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Natural Science Foundation of China (No.31870946,No.32271453), and China Pharmaceutical University Double-First Class Prospective Project (No.CPU2022QZ12)
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  • Received Date: November 14, 2022
  • Revised Date: March 02, 2023
    Graphical Abstract
    • Abstract
  • By regulating gene expression, nucleic acid drugs functioning in the cytoplasm or nucleus are of great significance in the treatment of acquired or inherited diseases and vaccine development.A variety of nucleic acid delivery vectors currently developed are suffering from low transfection efficiency due to endosome/lysosome entrapment.This paper introduces and summarizes the nucleic acid delivery strategies that bypass the endosomal/lysosomal pathway, including membrane translocation, membrane fusion, receptor/transporter-mediated non-endocytic uptake and caveolae-mediated endocytosis, and discusses the problems and challenges facing such strategies, aiming to facilitate the development of intracellular delivery of nucleic acid drugs bypassing lysosomal pathway.
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    • References (62)
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