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YAN Dao-hui, WANG Bo. Synthesis and characterization of Fe3O4＠SiO2 magnetic-fluorescent bifunctional nanoparticles[J]. Journal of China Pharmaceutical University, 2012, 43(4): 307-311.
Citation: YAN Dao-hui, WANG Bo. Synthesis and characterization of Fe3O4＠SiO2 magnetic-fluorescent bifunctional nanoparticles[J]. Journal of China Pharmaceutical University, 2012, 43(4): 307-311.
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Synthesis and characterization of Fe3O4＠SiO2 magnetic-fluorescent bifunctional nanoparticles

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  • Fe3O4＠SiO2 nanoparticles were prepared by way of combining organic template and reverse micro-emulsion,and Fe3O4 nanoparticles were covered by silica layers with core-shell morphologies.Then fluorescein 5-isothiocyanate (FITC) was chemically attached onto the nanoparticles by 3-aminopropyl-triethoxysilane (APTES),realizing Fe3O4＠SiO2(FITC) nanoparticles with the dual functions of the magnetic and fluorescence.We prepared SiO2(RITC) nanoparticles incorporating covalently with rhodamine B isothiocyanate (RITC) as control for magnetic separation experiments.The Fe3O4＠SiO2(FITC) nanoparticles were then characterized by Fourier transform infrared (FT-IR) spectrometry,X-ray diffraction (XRD),transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) techniques.Results showed that the average diameter of nanoparticles was about 100 nm,and the saturation magnetization was 29.8 emu/g,which exhibited superparamagnetic behavior and high fluorescent intensity.The fluorescent microscopic observations showed that Fe3O4＠SiO2(FITC) had both magnetic and fluorescent properties with a good separation effect.
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