• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
TONG Xinyong, LI Limin. Preparation of levobupivacaine hydrochloride sustained-release in-situ gel injection and its pharmacokinetic and pharmacodynamic studies in animals[J]. Journal of China Pharmaceutical University, 2015, 46(2): 209-213. DOI: 10.11665/j.issn.1000-5048.20150212
Citation: TONG Xinyong, LI Limin. Preparation of levobupivacaine hydrochloride sustained-release in-situ gel injection and its pharmacokinetic and pharmacodynamic studies in animals[J]. Journal of China Pharmaceutical University, 2015, 46(2): 209-213. DOI: 10.11665/j.issn.1000-5048.20150212
shu

Preparation of levobupivacaine hydrochloride sustained-release in-situ gel injection and its pharmacokinetic and pharmacodynamic studies in animals

More Information
    Graphical Abstract
    • Abstract
  • The purpose of this study was to develop a novel phospholipidas-based in-situ gel sustained-release formulation of levobupivacaine hydrochloride injection. Appropriate formulation was screened based on the factors such as phospholipid type, ratio of phospholipid to ethanol, ratio of water to phospholipid-ethanol mixture, which indicated typical in-situ gel profiles. Pharmacokinetic study using beagles showed that there were delayed tmax and prolonged t1/2 in levobupivacaine plasma-time profile after administration of the phospholipidas-based in-situ gel formulation if compared to commercially available conventional levobupivacaine hydrochloride injection. Pharmacodynamic studies conducted on guinea-pig demonstrated that it maintained 48-72 hr regional anesthesia, much longer than that of the anesthesia in the group receiving conventional injection. Hence, this novel in-situ gel intended for injection is worthy of development.
    • FullText(HTML)
    • References (9)
  • [1]
    Andrea C, Marta P. Bupivacaine, levobupivacaine and ropivacaine:are they clinically different[J]?Best Pract Res Clin Anaesthesiol,2005,19(2):247-268.
    [2]
    Bajwa SJ,Kaur J.Clinical profile of levobupivacaine in regional anesthesia:a systematic review[J].J Anaesthesiol Clin Pharmacol,2013,29(4):530-539.
    [3]
    Tong YC,Kaye AD,Urman RD.Liposomal bupivacaine and clinical outcomes[J].Best Pract Res Clin Anaesthesiol,2014,28(1):15-27.
    [4]
    McAlvin JB,Reznor G,Shankarappa SA,et al.Local toxicity from local anesthetic polymeric microparticles[J].Anesth Analg,2013,116(4):794-803.
    [5]
    Zeng HL,Shi Z,Fu XD.Progress in clinical application of the bupivacaine liposome injectable suspension Exparel[J].ChinJ New Drugs(中国新药杂志),2014,23(14):1654-1658.
    [6]
    Judy S,Michael R.Sustained-Release Injectable Products(可注射缓释制剂)[M].Beijing:Chemical Industry Press,2005:136-137,152.
    [7]
    Skolnik A,Gan TJ.New formulations of bupivacaine for the treatment of postoperative pain:liposomal bupivacaine and SABER-Bupivacaine[J].Expert Opin Pharmacother,2014,15(11):1535-1542.
    [8]
    Qi N, Tang X, Lin X, et al. Sterilization stability of vesicular phospholipid gels loaded with cytarabine for brain implant[J].Int J Pharm,2012,427(2):234-241.
    [9]
    Zhang RZ, Deng YJ, Sun WP. Research progressin vesicular phospholipid gel[J].Chin J Pharm(中国药剂学杂志),2008,6(4):214-218.
    • Related Articles

  • Related Articles

    [1]XU Linhao, LIU Xinze, LIU Wei, XIANG Ping, HANG Taijun, YANG Shuo, YAN Hui. Application of zebrafish model in the metabolism of new psychoactive substances[J]. Journal of China Pharmaceutical University, 2022, 53(5): 606-612. DOI: 10.11665/j.issn.1000-5048.20220511
    [2]CHENG Liyuan, LIU Wei, GUO Xiaoyan, GE Xiaoai, WANG Dingding, WANG Tao. Effects and mechanism of zidovudine on glucolipid metabolic balance in mice[J]. Journal of China Pharmaceutical University, 2022, 53(3): 340-347. DOI: 10.11665/j.issn.1000-5048.20220312
    [3]WANG Jingqi, WANG Ye, ZHANG Yi, LIANG Juncheng, DENG Yanping, HANG Taijun, SONG Min. Metabolomic study on clinical staging of methamphetamine detoxification by LC-QTOF-MS[J]. Journal of China Pharmaceutical University, 2022, 53(3): 314-322. DOI: 10.11665/j.issn.1000-5048.20220309
    [4]HE Mingzhe, PENG Ying, WANG Guangji, A Jiye, ZHENG Yiwen, SUN Jianguo. Mechanism of sodium salicylate-induced damage to HEI-OC1 cells based on metabonomics[J]. Journal of China Pharmaceutical University, 2021, 52(5): 566-572. DOI: 10.11665/j.issn.1000-5048.20210508
    [5]WU Yubing, YIN Lifang, QIN Chao. Clinical application and detection of matrix metalloproteinases in diagnosis[J]. Journal of China Pharmaceutical University, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514
    [6]TAO Yingjun, WU Jie, LIU Chang. Application of proteomics in diabetes and its complications[J]. Journal of China Pharmaceutical University, 2020, 51(3): 368-373. DOI: 10.11665/j.issn.1000-5048.20200315
    [7]YIN Kunpeng, ZHENG Hao, XIE Binxin, LI Ping, ZHANG Lei, FAN Yong, ZHU Wei, QI Lianwen. Clinical metabolomics in diagnosis and therapy of coronary artery disease[J]. Journal of China Pharmaceutical University, 2017, 48(6): 629-634. DOI: 10.11665/j.issn.1000-5048.20170601
    [8]ZHANG Xue, WANG Yuhao, ZHENG Yunsi, HE Hua, LIU Xiaoquan. Evaluation of the protective effect of salvianolic acid A on ischemic heart failure by a multi-target pharmacokinetic-pharmacodynamic model[J]. Journal of China Pharmaceutical University, 2016, 47(5): 587-594. DOI: 10.11665/j.issn.1000-5048.20160514
    [9]LI Chen, YUAN Linhua, MA Xueqin, LIU Xiaoquan, XI Tao. Variation of cardiovascular risk biomarkers in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2013, 44(3): 257-262. DOI: 10.11665/j.issn.1000-5048.20130314
    [10]HUANG Yin, XU Fengguo, ZHANG Wei, ONG Choonnam, ZHANG Zunjian. Progress for pharmacometabolomics and its applications[J]. Journal of China Pharmaceutical University, 2013, 44(2): 105-112. DOI: 10.11665/j.issn.1000-5048.20130202

Catalog

    Get Citation
    PDF
    XML
    Article views (1392) PDF downloads (2943) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：300509

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return