• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
WANG Jingqi, WANG Ye, ZHANG Yi, LIANG Juncheng, DENG Yanping, HANG Taijun, SONG Min. Metabolomic study on clinical staging of methamphetamine detoxification by LC-QTOF-MS[J]. Journal of China Pharmaceutical University, 2022, 53(3): 314-322. DOI: 10.11665/j.issn.1000-5048.20220309
Citation: WANG Jingqi, WANG Ye, ZHANG Yi, LIANG Juncheng, DENG Yanping, HANG Taijun, SONG Min. Metabolomic study on clinical staging of methamphetamine detoxification by LC-QTOF-MS[J]. Journal of China Pharmaceutical University, 2022, 53(3): 314-322. DOI: 10.11665/j.issn.1000-5048.20220309
shu

Metabolomic study on clinical staging of methamphetamine detoxification by LC-QTOF-MS

  • 1.

    School of Pharmacy, China Pharmaceutical University, Nanjing 210009

  • 2.

    Office of China National Narcotics Control Commission-China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Beijing 100193

  • 3.

    National Institute on Drug Dependence, Peking University,Beijing 100191, China

More Information
  • Received Date: November 10, 2021
  • Revised Date: April 15, 2022
    Graphical Abstract
    • Abstract
  • At present , methamphetamine has become a major hidden danger in global public health safety. In order to judge methamphetamine addicts and methamphetamine abstainers more scientifically and reliably, this study analyzed the endogenous metabolites in plasma, serum and urine of methamphetamine addicts, methamphetamine abstainers and healthy volunteers by highly sensitive high-throughput liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) analytical instrument. The obtained metabolomic data were processed by univariate analysis (t-test) and multivariate analysis (PLS-DA and OPLS-DA) and eligible potential biomarkers were then screened.The identified biomarkers set enrichment analysis to find the connection between metabolites and metabolic pathways.Multivariate statistical results showed that methamphetamine acute group, recovery group and healthy group were clearly separated.3, 18 and 6 regulated metabolites were identified in serum, plasma and urine, respectively, suggesting that lipid metabolism was abnormal in methamphetamine acute group, and that fatty acid metabolism, sulfate/sulfite metabolism and sex hormone metabolism were abnormal in methamphetamine recovery group.The selected potential biomarkers in this study provide the possibility for scientific judgment of the clinical stage of methamphetamine detoxification.
    • FullText(HTML)
    • References (30)
  • [1]
    . Drug Alcohol Depend，2014，143：11-21.
    [2]
    Won S，Hong RA，Shohet RV，et al. Methamphetamine-associated cardiomyopathy［J］. Clin Cardiol，2013，36（12）：737-742.
    [3]
    Kevil CG，Goeders NE，Woolard MD，et al. Methamphetamine use and cardiovascular disease［J］. Arterioscler Thromb Vasc Biol，2019，39（9）：1739-1746.
    [4]
    Wodarz N，Krampe-Scheidler A，Christ M，et al. Evidence-based guidelines for the pharmacological management of acute methamphetamine-related disorders and toxicity［J］. Pharmacopsychiatry，2017，50（3）：87-95.
    [5]
    Suetani S，Reddan J，Anderson C. Methamphetamine and psychiatry：a story of the colourless substance of abuse［J］. Australas Psychiatry，2017，25（3）：254-256.
    [6]
    Paratz ED，Cunningham NJ，MacIsaac AI. The cardiac complications of methamphetamines［J］. Heart Lung Circ，2016，25（4）：325-332.
    [7]
    Cao YY，Pu XP. Biomarkers of methamphetamine addiction and its measurements technique evolvement［J］. Chin J New Drugs（中国新药杂志），2019，28（1）：34-39.
    [8]
    Mendelson J，Baggott MJ，Flower K，et al. Developing biomarkers for methamphetamine addiction［J］. Curr Neuropharmacol，2011，9（1）：100-103.
    [9]
    Zaitsu K，Miyawaki I，Bando K，et al. Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine，methamphetamine，and cocaine-induced conditioned place preference［J］. Anal Bioanal Chem，2014，406（5）：1339-1354.
    [10]
    Choi B，Kim SP，Hwang S，et al. Metabolic characterization in urine and hair from a rat model of methamphetamine self-administration using LC-QTOF-MS-based metabolomics［J］. Metabolomics，2017，13（10）：1-17.
    [11]
    Zheng T，Liu LS，Shi J，et al. The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse［J］. Mol Biosyst，2014，10（7）：1968-1977.
    [12]
    Zhao Y，Zhang K，Jiang HF，et al. Decreased expression of plasma microRNA in patients with methamphetamine （MA） use disorder［J］. J Neuroimmune Pharmacol，2016，11（3）：542-548.
    [13]
    Alasmari F，Alsanea S，Masood A，et al. Serum proteomic profiling of patients with amphetamine use disorder［J］. Drug Alcohol Depend，2020，214：108157.
    [14]
    Shi WL，Zhao X，Liu ZM，et al. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction［J］. Neurosci Lett，2012，525（1）：23-28.
    [15]
    Lin M，Xu JM，Liu X，et al. Metabolomics profiling of methamphetamine addicted human serum and three rat brain areas［J］. RSC Adv，2019，9（70）：41107-41119.
    [16]
    Bai J，Wang MX，Chowbay B，et al. Metabolic profiling of HepG2 cells incubated with S （?） and R（+） enantiomers of anti-coagulating drug warfarin［J］. Metabolomics，2011，7（3）：353-362.
    [17]
    Cao B，Li MJ，Zha WB，et al. Metabolomic approach to evaluating adriamycin pharmacodynamics and resistance in breast cancer cells［J］. Metabolomics，2013，9（5）：960-973.
    [18]
    Ouattara DA，Prot JM，Bunescu A，et al. Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells［J］. Mol Biosyst，2012，8（7）：1908-1920.
    [19]
    Lin SH，Yang Z，Liu HD，et al. Metabolomic analysis of liver and skeletal muscle tissues in C57BL/6J and DBA/2J mice exposed to 2，3，7，8-tetrachlorodibenzo-p-dioxin［J］. Mol Biosyst，2011，7（6）：1956-1965.
    [20]
    Wikoff WR，Gangoiti JA，Barshop BA，et al. Metabolomics identifies perturbations in human disorders of propionate metabolism［J］. Clin Chem，2007，53（12）：2169-2176.
    [21]
    Xue RY，Lin ZX，Deng CH，et al. A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry［J］. Rapid Commun Mass Spectrom，2008，22（19）：3061-3068.
    [22]
    Bogdanov M，Matson WR，Wang L，et al. Metabolomic profiling to develop blood biomarkers for Parkinson''s disease［J］. Brain，2008，131（Pt 2）：389-396.
    [23]
    Nicholson JK，Connelly J，Lindon JC，et al. Metabonomics：a platform for studying drug toxicity and gene function［J］. Nat Rev Drug Discov，2002，1（2）：153-161.
    [24]
    H?fner H，Riecher-R?ssler A，An der Heiden WA，et al. Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia［J］. Psychol Med，1993，23（4）：925-940.
    [25]
    Hallonquist JD，Seeman MV，Lang M，et al. Variation in symptom severity over the menstrual cycle of schizophrenics［J］. Biol Psychiatry，1993，33（3）：207-209.
    [26]
    Cai HL，Li HD，Yan XZ，et al. Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-na?ve schizophrenia patients after treatment with risperidone［J］. J Proteome Res，2012，11（8）：4338-4350.
    [27]
    Hermens DF，Lubman DI，Ward PB，et al. Amphetamine psychosis：a model for studying the onset and course of psychosis［J］. Med J Aust，2009，190（S4）：S22-S25.
    [28]
    Tirodkar TS，Voelkel-Johnson C. Sphingolipids in apoptosis［J］. Exp Oncol，2012，34（3）：231-242.
    [29]
    Law SH，Chan ML，Marathe GK，et al. An updated review of lysophosphatidylcholine metabolism in human diseases［J］. Int J Mol Sci，2019，20（5）：1149.
    [30]
    Tian ZS. Effect of platelet activating factor and its receptor-dependent and receptor-independent pathway in the demyelination of central nervous system（血小板激活因子与其受体依赖及非受体依赖信号通路在中枢神经系统脱髓鞘病变中的作用研究）［D］. Changchun：Jilin University，2020.
    • Related Articles

  • Related Articles

    [1]SU Haiying, WANG Yukun, LI Weisong, ZHOU Jianping, CHENG Hao. Advances in anti-Alzheimer’s disease nano drug delivery system based on pathogenic mechanism of ferroptosis[J]. Journal of China Pharmaceutical University, 2024, 55(5): 613-623. DOI: 10.11665/j.issn.1000-5048.2024040702
    [2]CHANG Yuan, MAGETA Mageta Samwel, LI Nibowen, TANG Yingqi, LI Huangjuan, QIAN Chenggen. Research advances in modulating microglia for intervening in Alzheimer’s disease[J]. Journal of China Pharmaceutical University, 2024, 55(5): 603-612. DOI: 10.11665/j.issn.1000-5048.2024030201
    [3]LAN Aili, LIU Gang, WU Chaoran, LIAO Hong. Research progress of integrated stress response in central nervous system diseases[J]. Journal of China Pharmaceutical University, 2024, 55(2): 194-201. DOI: 10.11665/j.issn.1000-5048.2023112302
    [4]ZHAO Mengqi, LIAO Hong. Researches progress of the relationship between neuro-inflammation and cognitive function[J]. Journal of China Pharmaceutical University, 2019, 50(4): 497-504. DOI: 10.11665/j.issn.1000-5048.20190416
    [5]CHEN Suting, CHEN Song, GAO Xiangdong. Construction, expression, purification and neuroprotective activity of TAT-FGF21 fusion protein[J]. Journal of China Pharmaceutical University, 2018, 49(4): 496-501. DOI: 10.11665/j.issn.1000-5048.20180417
    [6]YU Haiyang, CHEN Song, XU Zheng, GAO Xiangdong, YAO Wenbing. Protective effect of fibroin peptides on Aβ25-35-induced injury in SH-SY5Y cells and its mechanism[J]. Journal of China Pharmaceutical University, 2017, 48(5): 609-613. DOI: 10.11665/j.issn.1000-5048.20170517
    [7]YAN Ruizuo, GUO Baojian, YU Pei, ZHANG Zaijun. Effect of rasagiline on neuroprotection and behavior improvement in MPTP-induced acute mouse model of Parkinson′s disease[J]. Journal of China Pharmaceutical University, 2016, 47(5): 603-608. DOI: 10.11665/j.issn.1000-5048.20160517
    [8]NI Jie, LIU Gaoxiang, LIAO Hong. Expression of p75 neurotrophin receptor and its role in drug development[J]. Journal of China Pharmaceutical University, 2015, 46(6): 751-756. DOI: 10.11665/j.issn.1000-5048.20150620
    [9]CHEN Mengfei, FANG Lei, CHEN Li. Design, synthesis and anti-Alzheimer′s disease activity of 5-akylaminomethyl substituted carbazole derivatives[J]. Journal of China Pharmaceutical University, 2015, 46(6): 647-652. DOI: 10.11665/j.issn.1000-5048.20150602
    [10]SHEN Kai, KOU Junping, YU Boyang. Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis[J]. Journal of China Pharmaceutical University, 2015, 46(5): 532-540. DOI: 10.11665/j.issn.1000-5048.20150503

  • Cited by

    Periodical cited type(6)

    1. 段盼盼，赵丽娟，吴姿，杨子妮，王燕清. 直接进样气相色谱法用于助悬剂中乙二醇二甘醇和三甘醇残留量测定方法研究. 实用医技杂志. 2024(04): 241-244 .
    2. 孔祥祥，李建兵，陈东，孙晨磊，王婷，孙云，臧金秋，宋蕾，梁野. 气相色谱法测定聚乙二醇200中乙二醇、二甘醇、三甘醇和四甘醇含量. 质量安全与检验检测. 2024(03): 6-9 .
    3. 黄丽梅，曹玉，戴震，仝立卿，张珂. GC法测定对乙酰氨基酚口服液体制剂辅料中乙二醇及二甘醇残留量. 云南化工. 2024(08): 124-127 .
    4. 杨军林，陈明学，田栋伟，尹艳艳，张二康，尤小龙，张健，程平言. GC-MS/MS法直接测定酱香型白酒中二乙二醇的含量. 食品科技. 2022(06): 303-309 .
    5. 郜淑晓，祝颂，赵恂，袁耀佐，宋敏，杭太俊，陆宇婷. 聚氧乙烯中乙二醇和二甘醇残留的HPLC和GC测定法比较研究. 药物分析杂志. 2020(10): 1820-1827 .
    6. 田嘉铭，于小红，王银月，王旭，王治宝，王金，卢金铭. 气相色谱法测定糖平煎复方中苍术酮含量. 神经药理学报. 2020(05): 14-17 .

    Other cited types(1)

Catalog

    Get Citation
    PDF
    XML
    Article views (135) PDF downloads (349) Cited by(7)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：292763

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return