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ZHANG Tianxing, HUANG Wei, HUANG Xueyu, LIAO Anping. Interaction of oleanolic acid and its derivatives with bovine serum albumin by spectrofluorimetry[J]. Journal of China Pharmaceutical University, 2017, 48(5): 572-576. DOI: 10.11665/j.issn.1000-5048.20170511
Citation: ZHANG Tianxing, HUANG Wei, HUANG Xueyu, LIAO Anping. Interaction of oleanolic acid and its derivatives with bovine serum albumin by spectrofluorimetry[J]. Journal of China Pharmaceutical University, 2017, 48(5): 572-576. DOI: 10.11665/j.issn.1000-5048.20170511
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Interaction of oleanolic acid and its derivatives with bovine serum albumin by spectrofluorimetry

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  • Oleanolic acid was chemically modified to improve its interaction with bovine serum albumin, thus to increase the mutual binding ability. As a lead compound, oleanolic acid reacted with Jones-reagent, then methyl iodide and finally hydroxylamine to obtain four different derivatives. Their structures were confirmed by IR and 1H NMR analysis. The interaction between these derivatives and bovine serum albumin and the effect of temperature and trace metal ions as Cu2+ and Co2+ on the interaction were investigated by fluorescence spectroscopy. All these derivatives exhibited improvement of the interaction compared with oleanolic acid with 16 times stronger for OA2. The interaction also increased with the presence of trace metal ions as Cu2+and Co2+. These results indicate that chemical modification can improve the interaction of oleanolic acid with bovine serum albumin.
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