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GUO Wei, XIE Chunwen, WANG Wensheng, ZHENG Deqiang, HE Shuwang. Synthesis of related substances of tebipenem pivoxil[J]. Journal of China Pharmaceutical University, 2018, 49(3): 286-290. DOI: 10.11665/j.issn.1000-5048.20180305
Citation: GUO Wei, XIE Chunwen, WANG Wensheng, ZHENG Deqiang, HE Shuwang. Synthesis of related substances of tebipenem pivoxil[J]. Journal of China Pharmaceutical University, 2018, 49(3): 286-290. DOI: 10.11665/j.issn.1000-5048.20180305
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Synthesis of related substances of tebipenem pivoxil

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  • To enhance the quality control of tebipenem pivoxil and establish its quality criteria, the synthetic route of tebipenem pivoxil was analyzed and five related substances(P1, P2, P6, P8 and P9)were synthesized and characterized by 1H NMR and MS. The purities of the related substances were over 95% via HPLC detection. The target compounds can be used as the reference of the related substances in the quality control of tebipenem pivoxil. The starting materials were cheap and easy to obtain; the reaction conditions were mild.
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