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SUN Chenkai, CHEN Xin, CHENG Hao, ZHANG Xiangze, YANG Xiaoyu, ZHOU Jianping, DING Yang. Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy[J]. Journal of China Pharmaceutical University, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401
Citation: SUN Chenkai, CHEN Xin, CHENG Hao, ZHANG Xiangze, YANG Xiaoyu, ZHOU Jianping, DING Yang. Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy[J]. Journal of China Pharmaceutical University, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401
shu

Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy

  • 1.

    Department of Pharmaceutics & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009

  • 2.

    Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009

  • 3.

    NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81872819, No.82073401, No.82073795)
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  • Received Date: May 09, 2021
  • Revised Date: May 20, 2021
    Graphical Abstract
    • Abstract
  • Photodynamic therapy, a new type of non-invasive treatment, is based on the principle that the photosensitizer excited by laser can transfer energy to oxygen, which generates cytotoxic singlet oxygen and thus induce tumor cell apoptosis or necrosis. As an oxygen-dependent therapy, the antitumor effect of photodynamic therapy is obviously limited by hypoxia environment of solid tumor tissue. Therefore, reversing and improving the hypoxia of tumor tissue can significantly enhance the efficacy of photodynamic therapy. This review focuses on the progress of tumor oxygenation strategy mediated by nano-delivery system, including direct oxygen delivery strategies, catalytic oxygen production strategies, responsive material in situ oxygen supply strategies and microorganism oxygen supply strategies, aiming to improve the antitumor effect of photodynamic therapy. It provides new ideas and new approaches for further study of oxygen-enchancing nano-delivery system for photodynamic therapy.
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    • References (45)
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