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ZHANG Ting, LIAO Hang, CHENG Yuting, WU Xiaohong. Preparation and properties of injectable minocycline hydrochloride microsphere depot[J]. Journal of China Pharmaceutical University, 2021, 52(1): 52-59. DOI: 10.11665/j.issn.1000-5048.20210107
Citation: ZHANG Ting, LIAO Hang, CHENG Yuting, WU Xiaohong. Preparation and properties of injectable minocycline hydrochloride microsphere depot[J]. Journal of China Pharmaceutical University, 2021, 52(1): 52-59. DOI: 10.11665/j.issn.1000-5048.20210107
shu

Preparation and properties of injectable minocycline hydrochloride microsphere depot

  • 1.

    Department of Prosthodontics, Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147

  • 2.

    Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147

  • 3.

    Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China

Funds: This study was supposed by the National Natural Science Foundation of China(No.81970914)
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  • Received Date: August 31, 2020
  • Revised Date: December 06, 2020
    Graphical Abstract
    • Abstract
  • To prepare a minocycline hydrochloride microsphere depot and evaluate its release performance and physicochemical properties, poly (lactic-co-glycolic acid) (PLGA) was used as raw material, the minocycline hydrochloride microspheres were prepared by electrospray, and the morphology and size distribution of the microspheres were characterized by polarizing microscopy and scanning electron microscopy (SEM). The microspheres were then mixed with sucrose acetate isobutyrate (SAIB) depot at a ratio of 1:10 to form a minocycline hydrochloride microsphere depot, and its release performance and porosity changes were evaluated. The results showed that the microspheres had smooth surface and the diameter was (5.294 ± 1.222) μm. After the microspheres were added into SAIB depot, the burst release of minocycline hydrochloride significantly decreased from 60% to 3.27% at the first day, and then the release lasted for 42 days . Additionally, the porosity of the depot increased rapidly from (12.53 ± 0.43)% to (32.53 ± 0.43)% during days 0-15, and increased slowly from (32.53 ± 0.43)% to (33.81 ± 0.54)% during days 15-45. The minocycline hydrochloride microsphere depot prepared in this study is expected to be an effective way for the application of minocycline hydrochloride for its good release performance and simple preparation process.
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    • References (31)
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