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HAN Xiu, QI Xiaole, WU Zhenghong. Advances in self-assemblied DNA nanocages as drug delivery systems[J]. Journal of China Pharmaceutical University, 2017, 48(6): 663-669. DOI: 10.11665/j.issn.1000-5048.20170605
Citation: HAN Xiu, QI Xiaole, WU Zhenghong. Advances in self-assemblied DNA nanocages as drug delivery systems[J]. Journal of China Pharmaceutical University, 2017, 48(6): 663-669. DOI: 10.11665/j.issn.1000-5048.20170605
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Advances in self-assemblied DNA nanocages as drug delivery systems

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    • Abstract
  • DNA nanocages are nanoscale three-dimensional polyhedral structures formed by self-assembled oligonucleotide strands by base pairing. DNA nanocages, especially the tetrahedron DNA nanocages, were proved to be potential nanocarriers for drug delivery, due to their good stablility, high compatibility, intracellular ablility and hollow cavity for modification and drug loading. . In this paper, we reviewed the structural characteristics, synthetic methods and targeted modification of DNA nanocages, as well as their development and application in drug carriers, biological imaging, in vitro diagnosis and materials science.
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